Metampicillin

Metampicillin belongs to the pharmacological class of Beta-lactam Antibiotics.

Metampicillin is the approved name for penicillin resulting from the reaction of ampicillin with formaldehyde.

The common side effects involving the use of Metampicillin are Skin rash (urticarial or maculopapular), diarrhea, nausea, vomiting, and pseudomembranous colitis.

Metampicillin is available in the form of tablets.

Metampicillin belongs to the pharmacological class of Beta-lactam Antibiotics.

Metampicillin is the approved name for penicillin resulting from the reaction of ampicillin with formaldehyde.

Metampicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of Penicllin Binding Proteins interferes with the cross-linkage of peptidoglycan chains necessary for the bacterial cell wall strength as well as rigidity. This interrupts bacterial cell wall synthesis as well as results in the weakening of the bacterial cell wall, eventually causing cell lysis.

Tablet: To be swallowed directly with water

Oral

Susceptible infections

Adult: 1.5 g/day.

Tablet

Avoid high-acid foods like citrus fruits and juices like orange and grapefruit, soda, and chocolates.

Alcohol intake might lead to nausea, vomiting, and headache

MultIntravenousitamins and antacids contain minerals, primarily magnesium, calcium, aluminum, iron, or zinc, which bind to the antibiotic and refrain it from working. Spacing them at least for 2 hours after Metampicillin administration is recommended.

Metampicillin may is contraindicated under the following conditions:

• Patients with known hypersensitivity to penicillins.

The adverse reactions related to Metampicillin can be categorized as follows:

• Skin rash (urticarial or maculopapular)
• Diarrhea
• Nausea
• Vomiting
• Pseudomembranous colitis

The clinically relevant drug interactions of Metampicillin are briefly summarized here:

Probenecid may inhibit renal excretion of Metampicillin. Monitor blood coagulation parameters when used with high-dose heparin and other anticoagulants.

The following are the side effects involving Metampicillin:

• Skin rash (urticarial or maculopapular)
• Diarrhea
• Nausea
• Vomiting
• Pseudomembranous colitis

1. https://www.mims.com/hongkong/drug/info/metampicillin?mtype=generic
2. https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:52060
3. https://drugs.ncats.io/drug/G0H6U7VSTK
4. https://go.drugbank.com/drugs/DB13836