Allopathy
Prescription Required
DCGI (Drugs Controller General of India)
Schedule H
Noscapine is an non-sedating isoquinoline alkaloid
It is used in the treatment of dry cough
Noscapine shows common side effects like Nausea, Drowsiness, Headache, Coordination disorder, Slow heart rate
Noscapine is available in the form of Solutions
Noscapine is indicated For use in the treatment of dry cough
Noscapine's antitussive effects appear to be primarily mediated by its sigma receptor agonist activity. Evidence for this mechanism is suggested by experimental evidence in rats. Pretreatment with rimcazole, a sigma specific antagonist, causes a dose-dependent reduction in antitussive activity of noscapine.
Noscapine is approved for use in the following clinical indications
- Dry Cough
Noscapine is available in the form of solutions.
Dosage Adjustment in Kidney Patient
- There are no dosage adjustments provided in the manufacturer’s labeling (has not been studied); however, use caution in severe impairment due to the potential for altered pharmacokinetics.
Dosage Adjustment in Hepatic impairment Patient
- There are no dosage adjustments provided in the manufacturer’s labeling (has not been studied); however, use caution in severe impairment due to the potential for altered pharmacokinetics.
● Noscapine can increase the effects of centrally sedating substances such as alcohol and hypnotics.
● The drug should not be taken with any MAOIs (monoamine oxidase inhibitors), as unknown and potentially fatal effects may occur
● Noscapine should not be taken in conjunction with warfarin as the anticoagulant effects of warfarin may be increased.
Pharmacodynamic
Noscapine's antitussive effects appear to be primarily mediated by its sigma receptor agonist activity. Evidence for this mechanism is suggested by experimental evidence in rats. Pretreatment with rimcazole, a sigma specific antagonist, causes a dose-dependent reduction in antitussive activity of noscapine.
- https://clinicaltrials.gov/ct2/show/NCT04430790
- https://clinicaltrials.gov/ct2/show/NCT02820025
- https://pubmed.ncbi.nlm.nih.gov/27612991/
- https://clinicaltrials.gov/ct2/show/NCT03894189
- https://www.rxlist.com/dopram-drug.htm
- https://www.mims.com/india/drug/info/Noscapine?type=full&mtype=generic
- https://go.drugbank.com/drugs/DB00561
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003846/
