Allopathy
Prescription Required
DCGI (Drugs Controller General of India)
Schedule H
Oxaceprol is a Amino-acid derivatives. belonging to Non-Steroidal anti-inflammatory Drug
Oxaceprol is used in the treatment of osteoarthritis and inflammatory connective tissue diseases.
Oxaceprol is absorbed 3.5 hr after oral admin and get permeates into the synovial fluid. Bio-availability after oral admin: approx 30% and excreted via urine (exclusively, unchanged and complete). And elimination half-life: 2.2 hr.
Oxaceprol is available in tablets.
The common side effects of Oxaceprol was Dizziness, Nausea, Diarrhea, Abdominal pain, Itching, Weakness.
Oxaceprol is available in India, Germany, Canada, France, USA.
Oxaceprol blocks the release of certain chemical mediators responsible for pain, redness, swelling, etc. thereby providing relief in inflammatory conditions of bones and joints.
Oxaceprol is available in the form of tablets.
Oxaceprol is used in the treatment of osteoarthritis and inflammatory connective tissue diseases.
Oxaceprol is an anti-inflammatory medication. It works by preventing accumulation of leukocytes in the joints, thus inhibiting inflammation at an early stage. This helps in pain relief.
Oxaceprol is approved for use in the following clinical indications
- Osteoarthritis
This medicine is used to relieve symptoms such as pain and swelling associated with osteoarthritis of the knee or hip joints.
- Inflammatory connective tissue diseases
This medicine is used to relieve symptoms such as pain and swelling associated with inflammatory connective tissue diseases such as rheumatoid arthritis, bursitis, periarthritis, etc.
Oral
Degenerative joint disorders
Adult: 200 mg tid. In severe cases, initial dose can be increased to 400 mg tid. Taken before a meal, unchewed.
Elderly: Dose reduction is recommended.
Oral
Inflammatory connective tissue diseases
Adult: 200 mg tid. In severe cases, initial dose can be increased to 400 mg tid. Taken before a meal, unchewed.
Elderly: Dose reduction is recommended.
Topical/Cutaneous
Superficial burns
Adult: 10% cream: Apply once a day.
Oxaceprol is available in the dosage strength of 600 mg
Oxaceprol is available in the form of tablets.
Take after eating and with a full glass of water to decrease gastric upset.
Oxaceprol is contraindicated in patients with:
Oxaceprol should not be administered to animals with serious hepatic, renal or cardiac pathology, or those with a history of blood dyscrasia.
Pregnancy
This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings
Kidney impairment
This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Alcohol Warning
Oxaceprol may cause liver problems, and using it with substantial quantities of ethanol may increase that risk.
Breast Feeding Warning
Oxaceprol and its active metabolite morphine are present in breast milk and can be detected in the serum of breastfeeding infants.
Concentrations of Oxaceprol and morphine in breast milk are dependent upon the mother's CYP2D6 metabolism. In patients with normal CYP2D6 metabolism, the amount detected in breast milk is expected to be dose-dependent; however, deaths have occurred in breastfeeding infants exposed to high concentrations of morphine because the mothers were ultrarapid metabolizers. Genetic testing for CYP2D6 is recommended for patients requiring Oxaceprol for postpartum pain and who will be breastfeeding
Affects coagulation in patients under anticoagulative therapy with Vitamin K-antagonists. May decrease effects of anti-hypertensives. May affect toxicity of methotrexate and lithium.
The common side effects of Oxaceprol include the following :
Common Side effects: Gastric pain, nausea, diarrhea, dizziness, headache and skin rashes.
- Pharmacodynamics
It affects connective tissue metabolism and has been used in dermatology, to promote wound healing, and in rheumatic disorders. Experimental models of arthritis showed that oxaceprol reduced leukocyte extravasation, as well as the adhesion of leukocytes to capillaries. In vitro studies have shown that oxaceprol stimulates the uptake of 3H-glucosamine and 3H-proline in chondrocytes and the incorporation of 3H-proline in the macromolecular structure of the matrix of cartilage; which would be responsible for the activity on regenerating tissue.
- Pharmacokinetics
Absorption: 3.5 hr after oral admin.
Distribution: Permeates into the synovial fluid. Bio-availability after oral admin: approx 30%.
Excretion: Via urine (exclusively, unchanged and complete). Elimination half-life: 2.2 hr.
- https://pubmed.ncbi.nlm.nih.gov/1091001/
- https://clinicaltrials.gov/ct2/show/NCT01422915
- https://clinicaltrials.gov/ct2/show/NCT02263547
- https://www.medicines.org.uk/emc/product/128/smpc.
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1364710/
- https://reference.medscape.com/drug/colestid-Oxaceprol -342452
- https://go.drugbank.com/drugs/DB00375
- https://www.sciencedirect.com/topics/medicine-and-dentistry/Oxaceprol
- https://europepmc.org/article/med/6988203
