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OverviewMechanism of ActionHow To UseUsesBenfitsIndicationsMethod of AdministrationDosage StrengthsDosage FormsDietary RestrictionsContraindicationsWarnings and Precautions for usingAdverse ReactionsClinical StudiesAuthored by Reviewed by References
Oxyfedrine

Oxyfedrine

Indications, Uses, Dosage, Drugs Interactions, Side effects
Oxyfedrine
Medicine Type :
Allopathy
Prescription Type:
Prescription Required
Approval :
DCGI (Drugs Controller General of India)
Schedule
Schedule H
Pharmacological Class:
β-adrenergic receptors agonist,
Therapy Class:
Antianginal, Antihypertensive, Vasodilator,

Oxyfedrine is an antianginal/antihypertensive/vasodilator belonging to β-adrenergic receptors agonist.

Oxyfedrine is a vasodilator, indicated for the treatment of angina pectoris and Myocardial infarction.

Oxyfedrine shows common side effects like Taste perversion.

Oxyfedrine is available in the form of Oral Tablet.

Oxyfedrine is available in India, Malaysia, and Canada.

Oxyfedrine belonging to the β-adrenergic receptors agonist acts as an antianginal/antihypertensive/vasodilator.

Oxyfedrine is a vasodilator and a beta- adrenoreceptor agonist It was found to depress the tonicity of coronary vessels, improve myocardial metabolism (so that heart can sustain hypoxia better) and also exert a positive chronotropic and inotropic effects, thereby not precipitating angina pectoris.

The Data of Onset and Duration of action of Oxyfedrine is not clinically established.

Oxyfedrine is available in the form of Oral Tablet.

Oxyfedrine tablet is taken by orally, usually 3 times a day.

Oxyfedrine is a vasodilator, indicated for the treatment of angina pectoris and Myocardial infarction.

Oxyfedrine is an antianginal/antihypertensive/vasodilator belonging to β-adrenergic receptors agonist.

Oxyfedrine is a vasodilator and a beta- adrenoreceptor agonist It was found to depress the tonicity of coronary vessels, improve myocardial metabolism (so that heart can sustain hypoxia better) and also exert a positive chronotropic and inotropic effects, thereby not precipitating angina pectoris.

Oxyfedrine is approved for use in the following clinical indications

  • Angina pectoris and Myocardial infarction

Oxyfedrine is a vasodilator, prescribed for angina pectoris and Myocardial infarction.

  • Angina pectoris and Myocardial infarction

Adult Dose: 8-24 mg 3 times/day.

Oxyfedrine is available in various strengths as 8mg and 24mg.

Oxyfedrine is available in the form of Oral Tablet.

Oxyfedrine is contraindicated in patients with

  • Aortic insufficiency with marked haemodynamic changes.
  • Subvalvular aortic stenosis.
  • Caution should be exercised in patients with history of heart disease.
  • Caution should be taken in patients with history Liver or kidney impairment.
  • Caution should be exercised during pregnancy and breastfeeding.
  • Transient taste impairment

The common side effects of Oxyfedrine include the following

● Taste perversion

There are some clinical studies of the drug Oxyfedrine mentioned below:
  1. Kaski JC, Araujo L, Maseri A. Effects of oxyfedrine on regional myocardial blood flow in patients with coronary artery disease. Cardiovascular drugs and therapy. 1991 Dec;5(6):991-6.
  2. Rettig G, Sternitzke N, Sen S, Schmengler K, Schieffer H, Bette L. Effects of oxyfedrine on sinus nodal function and AV-conduction (author's transl). Zeitschrift fur Kardiologie. 1982 Jan 1;71(2):119-25.
  3. Parratt JR, Mackenzie JE. Possible mechanisms of action of oxyfedrine as an antianginal drug. British Journal of Clinical Pharmacology. 1981 Mar;11(3):307.
  • https://www.medindia.net/doctors/drug_information/oxyfedrine.htm#Dosage
  • https://www.mims.com/malaysia/drug/info/oxyfedrine?mtype=generic
  • https://www.mims.com/india/drug/info/oxyfedrine?type=full&mtype=generic
  • https://www.lybrate.com/medicine/oxyfedrin#:~:text=The most commonly reported side,disease, liver or kidney impairment.
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Dr JUHI SINGLA
Dr JUHI SINGLA has completed her MBBS from Era’s Lucknow Medical college and done MD pharmacology from SGT UNIVERSITY Gurgaon. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751
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Jyoti Suthar
Jyoti is a Post graduate in Pharmaceutics ( M Pharm) She did her graduation ( B Pharm) From SSR COLLEGE OF PHARMACY And thereafter did her M Pharm specialized in Pharmaceutics from SSR COLLEGE OF PHARMACY
Published on: 7 Dec 2022 7:06 PM GMT
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