Allopathy
Prescription Required
DCGI (Drugs Controller General of India)
Schedule H
Suprofen is a Analgesic and Antipyretic belonging to Non-Steroidal anti-inflammatory Drug
Suprofen is used in the treatment of Inhibition of intraoperative miosis
Suprofen shows common side effects like Eye discomfort, itching, redness, iritis, pain
Suprofen is available in eye drops
Suprofen is available in India, Germany, Canada, France, USA.
Suprofen binds to the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isoenzymes, preventing the synthesis of prostaglandins and reducing the inflammatory response. Cyclooxygenase catalyses the formation of prostaglandins and thromboxane from arachidonic acid (itself derived from the cellular phospholipid bilayer by phospholipase A2). Prostaglandins act (among other things) as messenger molecules in the process of inflammation. The overall result is a reduction in pain and inflammation in the eyes and the prevention of pupil constriction during surgery. Normally trauma to the anterior segment of the eye (especially the iris) increases endogenous prostaglandin synthesis which leads to constriction of the iris sphincter.
Suprofen is available in the form of eye drops.
Suprofen is used in the treatment of Inhibition of intraoperative miosis.
Suprofen is an NSAID that inhibits miosis during ocular surgery.
Suprofen is approved for use in the following clinical indications
Inhibition of intraoperative miosis.
Ophthalmic
Inhibition of intraoperative miosis
Adult: As a 1% solution: Instil 2 drops every 4 hr during the day before surgery, then 2 drops 3 hr, 2 hr then 1 hr before surgery.
Suprofen is available in the form of eye drops.
Suprofen is contraindicated in patients with:
Active herpes simplex keratitis.
Caution should be exercised in patients with history of bleeding or blood-clotting disease, stomach ulcer, recently had surgery, who are taking other medications, any allergy, during pregnancy and breastfeeding.
Alcohol Warning
- Common Adverse effects: Eye discomfort, itching, redness, iritis, pain
- Less Common Adverse effects: Chemosis, photophobia, hypersensitivity
- Rare Adverse Effects: Punctate epithelial staining.
Concurrent use inactivates actions of acetylcholine and carbachol ophthalmic preparations.
The common side effects of Suprofen include the following :
Eye discomfort, itching, redness, iritis, pain.
Symptoms of overdose include bleeding in the eye or redness or swelling of the eye or the eyelid, blurred vision or other change in vision, fever or chills, itching or tearing, nausea or vomiting, pain, sensitivity to light, shortness of breath, sticky or matted eyelashes, swelling of face, throbbing pain, tightness in chest, troubled breathing, and wheezing.
- Pharmacodynamics
Suprofen is a non-steroidal anti-inflammatory analgesic and antipyretic. Ophthalmic anti-inflammatory medicines are used in the eye to lessen problems that can occur during or after some kinds of eye surgery. Sometimes, the pupil of the eye gets smaller during an operation (pupil constriction), making it more difficult for the surgeon to reach some areas of the eye. Suprofen is used to help prevent this.
- Pharmacokinetics
Absorption: NA
Distribution: NA
Metabolism: Primarily hepatic (mainly via cytochrome P450 isozyme 2C9).
Elimination: NA
- https://pubmed.ncbi.nlm.nih.gov/1091001/
- https://clinicaltrials.gov/ct2/show/NCT01422915
- https://clinicaltrials.gov/ct2/show/NCT02263547
- https://www.medicines.org.uk/emc/product/128/smpc.
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1364710/
- https://reference.medscape.com/drug/colestid-Suprofen -342452
- https://go.drugbank.com/drugs/DB00375
- https://www.sciencedirect.com/topics/medicine-and-dentistry/Suprofen
- https://europepmc.org/article/med/6988203
