Allopathy
Prescription Required
Temocillin belongs to the pharmacological class of Beta-lactam Antibiotics.
Temocillin is only active against Gram negative bacteria.
Temocillin is a penicillanic acid ester that is the acetoxymethyl ester of benzylpenicillin. It is a prodrug for benzylpenicillin. It has a role as an antibacterial drug and a prodrug. It is a penicillanic acid ester and a semisynthetic derivative. It is functionally related to benzylpenicillin.
Temocillin has been investigated in Infection, Liver Dysfunction, and Urinary Tract Infection.
Temocillin belongs to the pharmacological class of Beta-lactam Antibiotics.
Temocillin is only active against Gram negative bacteria.
Temocillin is a penicillanic acid ester that is the acetoxymethyl ester of benzylpenicillin. It is a prodrug for benzylpenicillin. It has a role as an antibacterial drug and a prodrug. It is a penicillanic acid ester and a semisynthetic derivative. It is functionally related to benzylpenicillin.
Temocillin has been investigated in Infection, Liver Dysfunction, and Urinary Tract Infection.
Temocillin is being investigated to be used intravenously.
Temocillin is being investigated to be used intravenously.
Temocillin has been investigated for Infection, Liver Dysfunction, and Urinary Tract Infection.
Temocillin has been investigated for Infection, Liver Dysfunction, and Urinary Tract Infection.
Common dose is 2 g intravenously for every 12 hours.
Temocillin is found to be available in the form of 2g vial.
- Marin-Candon A, Rosso-Fernandez CM, Bustos de Godoy N, Lopez-Cerero L, Gutierrez-Gutierrez B, Lopez-Cortes LE, Barrera Pulido L, Borreguero Borreguero I, Leon MJ, Merino V, Camean-Fernandez M, Retamar P, Salamanca E, Pascual A, Rodriguez-Bano J; ASTARTE Study Group. Temocillin versus meropenem for the targeted treatment of bacteraemia due to the third-generation cephalosporin-resistant Enterobacterales (ASTARTE): protocol for a randomized, pragmatic trial. BMJ Open. 2021 Sep 27;11(9):e049481. doi: 10.1136/bmjopen-2021-049481.
- Laterre PF, Wittebole X, Van de Velde S, Muller AE, Mouton JW, Carryn S, Tulkens PM, Dugernier T. Temocillin 6 g daily in critically ill patients: continuous infusion versus three times daily administration. J Antimicrob Chemother. 2015 Mar;70(3):891-8. doi: 10.1093/jac/dku465. Epub 2014 Nov 27.
- Balakrishnan I, Awad-El-Kariem FM, Aali A, Kumari P, Mulla R, Tan B, Brudney D, Ladenheim D, Ghazy A, Khan I, Virgincar N, Iyer S, Carryn S, Van de Velde S. Temocillin use in England: clinical and microbiological efficacies in the infections caused by extended-spectrum and/or derepressed AmpC beta-lactamase-producing Enterobacteriaceae. J Antimicrob Chemother. 2011 Nov;66(11):2628-31. doi: 10.1093/jac/dkr317. Epub 2011 Aug 2.
- Fournier D, Chirouze C, Leroy J, Cholley P, Talon D, Plesiat P, Bertrand X. Alternatives to carbapenems in ESBL-producing Escherichia coli infections. Med Mal Infect. 2013 Feb;43(2):62-6. doi: 10.1016/j.medmal.2013.01.006. Epub 2013 Feb 19.
- Schulze B, Heilmann HD. Treatment of severe infections with temocillin. Clinical and bacteriological evaluation. Drugs. 1985;29 Suppl 5:207-9. doi: 10.2165/00003495-198500295-00046.
- De Jongh R, Hens R, Basma V, Mouton JW, Tulkens PM, Carryn S. Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection. J Antimicrob Chemother. 2008 Feb;61(2):382-8. doi: 10.1093/jac/dkm467. Epub 2007 Dec 10.
- https://www.medchemexpress.com/temocillin.html
- https://pubchem.ncbi.nlm.nih.gov/compound/Temocillin
- https://pubmed.ncbi.nlm.nih.gov/19095679/
- https://go.drugbank.com/drugs/DB12343
- https://www.sciencedirect.com/topics/medicine-and-dentistry/temocillin
