Trolamine salicylate

Trolamine salicylate is a Analgesic and Antipyretic belonging to Non-Steroidal anti-inflammatory Drug

Trolamine salicylate is used in the treatment of Muscle/Joint pain.

Trolamine salicylate, Following topical administration of 10% trolamine salicylate in healthy volunteers, salicylic acid could not be detected in serum indicating low systemic absorption .Most body tissues and synovial spaces; protein binding: 98%.. Topical administration of 1 gram of 10% trolamine salicylate in abdominal rat skin resulted in an approximate extravascular volume of distribution (V/F) of 24.0 mL. Following topical administration of 10% trolamine salicylate in healthy volunteers, urinary recovery of total salicylate during the first 24 hours was 6.9 mg (p < 0.05), which is 1.4% of total dose

Trolamine salicylate is available in creams and lotion.

Trolamine salicylate is available in India, Germany, Canada, France, USA.

Inflammation and tissue damage in different conditions including arthritis, bursitis, joint disorder, bruises, and strains or sprains of muscle origin, induce mild to moderate pain and are associated with increase prostaglandin synthesis. This is thought to be a result of COX-2 enzyme induction. COX-2 is induced in inflammatory cells in case of cell injury, infection or activation from inflammatory cytokines such as interleukin (IL)-1 and tumor necrosis factor (TNF)-α. Upon activation, COX-2 produces prostanoid mediators of inflammation such as prostaglandins and thromboxanes. Trolamine salicylate mediates its analgesic effect by inhibiting the production of inflammatory mediators that sensitize nociceptive nerve endings and generate pain.

Trolamine salicylate is available in the form of creams and lotion.

Trolamine salicylate is used in the treatment of Muscle/Joint pain.

Trolamine salicylate is an organic compound or a salt formed between triethanolamine and salicylic acid. Triethanolamine neutralizes the acidity of the salicylic acid. It is a topical analgesic used for temporary relief of minor pain associated with arthritis, simple backache, muscle strains, sprains, and bruises. Unlike other topical analgesics, trolamine salicylate has no distinct odor which improves patient acceptability. It also displays low systemic absorption upon dermal or topical administration and has low skin irritant properties.

Trolamine salicylate is approved for use in the following clinical indications

Muscle/Joint pain: Temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, bruises, cramps, muscle strains, and sprains.

Muscle/joint pain: Topical: Apply a liberal amount to affected area as needed up to 4 times daily.

Trolamine salicylate is available in the dosage strength of 10%.

Trolamine salicylate is available in the form of creams and lotion.

Take after eating and with a full glass of water to decrease gastric upset.

Trolamine salicylate is contraindicated in patients with:

Trolamine salicylate should not be administered to patient with serious hepatic, renal or cardiac pathology, or those with a history of blood dyscrasia.

Other warnings/precautions:

• Self-medication (OTC use): Do not use on wounds, damaged skin, broken skin, or irritated skin. Stop use and call health care provider if irritation occurs or if conditions worsen, persist >7 days, or clears up then worsens again in a few days.

Trolamine salicylate may cause liver problems, and using it with substantial quantities of ethanol may increase that risk.

It is hazardous in case of ingestion. The carcinogenicity, mutagenicity and effects on reproductive fertility of trolamine salicylate have not been reported.

• Pharmacodynamics

Trolamine salicylate is a salicylate that inhibits cyclo-oxygenase (COX) enzymes responsible for generating pro-inflammatory factors such as to induce pain and inflammation. It is thought to mediate its analgesic effect through inhibition of COX-2 enzyme, which is an induced enzyme responsible for inflammatory responses and pain in muscle and joint disorders. By inhibiting fatty acid COX enzyme, trolamine salicylate inhibits the production of prostaglandins and thromboxanes in inflammatory cells involved in generating pain and inflammation . It thereby works to temporarily reduce mild to moderate pain. In subjects with muscle soreness from exercise, administration of topical trolamine salicylate was associated with reduced duration and severity of muscule soreness compared to placebo . In subjects with osteoarthritis in hands, trolamine salicylate cream was shown to be effective in achieving temporary relief of minor pain and stiffness

• Pharmacokinetics

Absorption: Following topical administration of 10% trolamine salicylate in healthy volunteers, salicylic acid could not be detected in serum indicating low systemic absorption .

Distribution: Most body tissues and synovial spaces; protein binding: 98%.

Metabolism Topical administration of 1 gram of 10% trolamine salicylate in abdominal rat skin resulted in an approximate extravascular volume of distribution (V/F) of 24.0 mL

Excretion: Following topical administration of 10% trolamine salicylate in healthy volunteers, urinary recovery of total salicylate during the first 24 hours was 6.9 mg (p < 0.05), which is 1.4% of total dose.

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1364710/
2. https://reference.medscape.com/drug/colestid-Trolamine salicylate -342452
3. https://go.drugbank.com/drugs/DB00375
4. https://www.sciencedirect.com/topics/medicine-and-dentistry/Trolamine salicylate
5. https://europepmc.org/article/med/6988203