Nocturnal Acid Breakthrough and the role of Vonoprazan - Dr Roy Patankar - Video

Nocturnal acid breakthrough (NAB) is defined as a prolonged drop in intra-gastric pH below 4 for over 60 minutes during nighttime hours, a phenomenon that impacts 40% to 70% of GERD patients even when they are on proton pump inhibitors (PPIs). NAB can lead to discomfort and disrupt sleep, as PPIs sometimes fail to maintain adequate acid suppression throughout the night.

In this video, Dr Roy Patankar, a Gastrointestinal Surgeon, Laparoscopic Surgeon, and Digestive Endoscopist from Mumbai, offers his expertise on understanding and managing NAB. Dr Patankar delves into effective management approaches, including the role of Vonoprazan, a potassium-competitive acid blocker. He also discusses the practical advantages of Vonoprazan over traditional PPIs in achieving consistent overnight acid suppression, which may bring relief to GERD patients experiencing NAB.

Here are some of the Key Questions Discussed:

1. What is Nocturnal Acid Breakthrough (NAB)?

2. What are the clinical features and challenges in NAB management?

3. Which patients are at high risk of NAB?

4. What are the practical advantages of Vonoprazan among currently available treatment options for NAB?

5. What is the therapeutic applicability of Vonoprazan in NAB?