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Does Continuing Beta-Blockers After a Heart Attack Make a Difference? New Study Sheds Lights - Video

Published On 3 Sept 2024 2:30 AM  |  Updated On 3 Sept 2024 7:09 AM
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Overview

New research presented at ESC Congress 2024 found that stopping beta-blocker treatment after a heart attack doesn't improve patient outcomes or quality of life compared to continuing the medication.

The open-label, non-inferiority, randomized ABYSS trial, conducted by the ACTION Group, included patients with a prior myocardial infarction (MI) taking long-term beta-blockers, with a left ventricular ejection fraction of at least 40% and no cardiovascular events in the previous 6 months. Participants were randomized (1:1) to interrupt or continue their β-blocker medication.

The main goal of the study was to evaluate if stopping beta-blocker therapy was not worse than continuing it, based on a combination of death, non-fatal heart attacks, non-fatal strokes, or hospitalizations for heart-related issues, measured over at least one year. Non-inferiority was defined as a difference of less than 3 percentage points between the two groups. Additionally, the study looked at changes in quality of life, using the European Quality of Life–5 Dimensions questionnaire as a measure.

In total 3,698 patients were randomised from 49 sites in France. The mean age was 64 years and 17% were female. The median time between the last myocardial Infarction (MI) and randomization was 2.9 years.

In the study, death rates were 4.1% in the group that stopped beta-blockers and 4.0% in the group that continued them. Heart attacks occurred in 2.5% of the interruption group and 2.4% of the continuation group. However, hospitalizations for heart-related issues were higher in the interruption group (18.9%) compared to the continuation group (16.6%).

Additionally, stopping beta-blockers led to higher systolic and diastolic blood pressure and heart rate at 6 months and throughout the study period(5). There was no improvement in quality of life for those who stopped the medication.

Reference: Beta blocker interruption in patients with prior myocardial infarction: results of the ABYSS trial and effect on blood pressure and heart rate control’ discussed during Hot Line 1 on Friday 30 August in room London.

Speakers

Dr. Garima Soni

BDS, MDS(orthodontics)

Dr. Garima Soni holds a BDS (Bachelor of Dental Surgery) from Government Dental College, Raipur, Chhattisgarh, and an MDS (Master of Dental Surgery) specializing in Orthodontics and Dentofacial Orthopedics from Maitri College of Dentistry and Research Centre. At medical dialogues she focuses on dental news and dental and medical fact checks against medical/dental mis/disinformation
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