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Gut bacteria inactivates certain BP medicines leading to resistant hypertension - Video

Published On 2022-06-03T09:00:25+05:30  |  Updated On 3 Jun 2022 9:00 AM IST
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Overview

A new study from The University of Toledo College of Medicine and Life Sciences has shown gut bacteria can reduce the effectiveness of certain blood pressure drugs.

The research, published in the journal Hypertension, offers the first clues to what has been an elusive mystery-why do some people not respond well to medication? High blood pressure is often called a silent killer because it doesn't usually cause symptoms. However, there is a big population of individuals who know they have hypertension but still cannot get it under control, even though they're taking blood pressure drugs thereby causing a major concern.

Among those with high blood pressure, an estimated 20% have what's known as resistant hypertension, meaning their blood pressure remains high despite aggressive treatment. The only way to manage this by doctors in these patients is adding or switching medications and increasing the dose with the hope they can find something that works. Until now, there haven't had any clear indication what the mechanism is for resistant hypertension.

In recent years researchers have more intently examined the link between an individual's blood pressure readings and the unique collection of bacteria that lives in their gut.

However, this is the first study to examine the impact of gut bacteria on blood pressure medication itself. UToledo scientists compared the effectiveness of the antihypertensive drug quinapril with normal gut bacteria against those whose gut microbiota had been depleted by high doses of antibiotics. Researchers found a clear difference between the two, with those who were given antibiotics first responding much better to quinapril.

Speakers

Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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