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How a rare genetic mutations led to surprising blood pressure discovery - Video

Published On 2022-10-06T09:00:00+05:30  |  Updated On 6 Oct 2022 9:00 AM IST
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Overview

New research by University of Pittsburgh geneticists and nephrologists shows that, surprisingly, a cellular channel outside the kidneys is doing some of the heavy lifting when it comes to keeping blood pressure under control. The finding, reported in the journal Hypertension, points to a promising new target for clinical trials to test existing medications for their potential to lower
blood pressure.

Only 1 in 4 people have their high blood pressure under control, making it one of the nation's biggest public health problems, according to the U.S. Centers for Disease Control and Prevention. High blood pressure is caused, in part, by the levels of fluid and salt getting out of whack, putting stress on artery walls and damaging blood vessels and organs.

The Pitt study focused on the passages - or channels - that the membranes of certain cells use to regulate fluid volume, based on how much sodium the cells contain. The researchers wanted to know if mutations in the genes that encode subunits of that channel might affect blood pressure.

The researchers wanted to build a dataset with genomic sequences and blood pressure records on more than 28,000 people who were participating in either the Trans-Omics in Precision Medicine (TOPMed) Whole-Genome Sequencing Project or the Somoan Soifua Manuia Study.

"One of the really exciting things, for me, about this project was that it was so targeted and hypothesis-driven, "one of the authors said. "Often with these big genomics projects, we're more agnostic - casting a wide net - and it can take decades for validation of a discovery. This project made a significant find remarkably quickly."

Reference:

Brandon Michael Blobner et al, Hypertension


Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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