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Journal Club - PROFID tool effective in screening sudden cardiac death

Published On 2022-05-04T18:38:12+05:30  |  Updated On 4 May 2022 1:08 PM GMT
Journal Club - PROFID tool effective in screening sudden cardiac death

Overview

Profid is a consortium comprising a wide variety of European cardiology key opinion leaders, large hospital chains, patient organizations, health industry, insurance, and government stakeholders, as well as bioinformatics, epidemiology, and health economics experts across Europe. With the development of an online software risk-prediction tool to be hosted on the website of the European Society of Cardiology, the broad make-up of the consortium will facilitate the goal of adopting the tool for use in routine clinical practice.

how cardiac MRI helps in improving in predicting sudden cardiac death after myocardial infarction. Using cardiac magnetic resonance imaging (CMR), investigators have improved upon earlier results of the PROFID clinical prediction model for risk for sudden cardiac death (SCD) after myocardial infarction (MI) by considering core scar and gray zone quantification.

The first step in PROFID was to develop an individualized sudden cardiac death risk-prediction model using machine learning to analyze existing data of several clinical characteristics, biomarkers, and imaging in 224,898 postinfarction patients.

The investigators analyzed all the data by five different methods but excluded cardiac magnetic resonance, they found that the predictive value of Left ventricular Ejection Fraction LVEF yielded a moderate C-statistic area under the curve value slightly above 0.6 (range, 0.618 - 0.690),and importantly, none of the other baseline characteristics, demographics, ECG characteristics, biomarkers, etc of the traditional potential predictors could increase this predictive performance.

Researchers concluded that Patients with reduced ejection fraction below 35% are going to significant over-treatment because only a minority will, at the end, use the device, and patients with Left ventricular Ejection Fraction greater than 35% may experience undertreatment because the majority of sudden cardiac death occurs in this population.

Speakers

Dr. Nandita Mohan

BDS, MDS( Pedodontics and Preventive Dentistry)

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751
Profid health industry European Society of Cardiology cardiac magnetic resonance imaging CMR sudden cardiac death SCD demographics ECG characteristics biomarkers 
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