LIFE Trial: sacubitril/valsartan combination not effective to treat HF - Video

Published On 2022-02-11T19:01:24+05:30 | Updated On 16 Feb 2022 5:24 PM IST

Overview

The LIFE trial highlights that combination sacubitril/valsartan did not reduce N-terminal pro b-type natriuretic peptide (NT-proBNP) or clinical outcomes among patients with advanced heart failure with reduced ejection fraction and comorbidities. Heart failure can develop suddenly or over time causing cardiac death which is a leading cause of death globally. Several medications are being evaluated to manage heart failure.

The trial aimed to assess the efficacy and safety of sacubitril/valsartan compared with valsartan in patients with advanced heart failure with reduced ejection fraction. 167 patients were randomized in a 1:1 ratio to either sacubitril/valsartan starting dose 24/26 mg or 49/51 mg twice a day, to 97/103 mg increased twice a day if tolerated after 4 weeks, or valsartan starting dose 40 or 80 mg twice a day.

Drugs didn't improve mortality and cardiovascular events, days alive outside hospital was 103.2 vs. 111.2 days, published in American College of Cardiology the results of this trial indicate that the combination sacubitril/valsartan did not reduce NT-proBNP or clinical outcomes among patients with advanced heart failure with reduced ejection fraction and comorbidities.

Speakers

Dr. Nandita Mohan

BDS, MDS( Pedodontics and Preventive Dentistry)

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751