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Outcomes for bypass surgery may improve using Seaweed molecules - Video

Published On 2022-12-06T09:15:54+05:30  |  Updated On 6 Dec 2022 2:31 PM IST
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Overview

Bypass surgery is performed to restore blood flow to areas of the heart when vessels become blocked. Vessels harvested from the patient are the gold standard for grafts, but limited availability often requires the use of artificial vessels.

In addition to heart bypass surgery, grafts are used in medical procedures to treat vascular diseases and restore blood flow to vital organs and tissues, including the brain and legs.

When synthetic graft material doesn't allow vascular cells to grow on the inside of an artery or vessel, there is a high chance of clots, which can develop into full blockages or cause inflammation that restricts blood flow.

Researchers are using a natural material derived from seaweed to promote vascular cell growth, prevent blood clots and improve the performance of synthetic vascular grafts used in heart bypass surgery.

The new approach, developed and tested at the University of Waterloo, is especially important in cases involving small artificial blood vessels - those less than six millimetres in diameter - which are prone to clots that can develop into full blockages.

"There is a crucial need to develop synthetic vascular graft materials that will increase the rate of long-term functions," said Dr. Evelyn Yim, a chemical engineering professor and University Research Chair who leads the project.

Researchers added a material called fucoidan, which is made from seaweed, to modify synthetic blood vessels. Fucoidan has a structure similar to heparin, a drug used as an anticoagulant.

When applied with a nanotechnology technique known as micropatterning, fucoidan promotes the growth of vascular cells around the inner surface of the graft, significantly reducing the chances of clots forming.

For patients, the potential benefits include fewer complications, better quality of life and less risk of the recurrence of blockages requiring additional drug treatment or surgery.

"A functional, off-the-shelf, small-diameter vascular graft will help save lives," said Yim, director of the Regenerative Nanomedicine Lab at Waterloo. "What's important is that they will be much longer-lasting and allow blood to flow freely."

Yim has successfully tested the new technique using fucoidan and micropatterning on small animals and plans to expand to large animal testing before advancing to clinical trials.

Several researchers from the Department of Chemical Engineering at Waterloo and the Department of Biomedical Engineering at the Oregon Health and Science University have collaborated on this project.

Reference:

Dr. Evelyn Yim et al, JOURNAL Bioactive Materials

Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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