PARADISE MI Trial: sacubitril/valsartan effective for heart attack - Video

Published On 2022-02-11T18:33:23+05:30 | Updated On 11 Feb 2022 6:33 PM IST

Overview

The PARADISE -MI trial assesed the efficacy and safety of sacubitril/valsartan compared with ramipril in a contemporary acute myocardial infarction population. Heart attack is an extremely dangerous condition with significant mortality rate. The lack of blood flow can occur because of many different factors but is usually related to a blockage in one or more of arteries.

A total of 2,830 in sacubitril/valsartan (target dose 97/103 mg twice a day) or 2,831 ramipril (target 5 mg twice a day) were grouped. The primary outcome of cardiovascular (CV) death, first Heart Failure hospitalization, or outpatient Heart Failure for sacubitril/valsartan vs. ramipril, was: 11.9% vs. 13.2%.

The results of this trial in American College of Cardiology indicates that the combination sacubitril/valsartan did not reduce the primary endpoint in a contemporary enriched acute myocardial infarction population, compared with ramipril. These are interesting findings and add to the available data with angiotensin receptor-neprilysin inhibitors.

Speakers

Dr. Nandita Mohan

BDS, MDS( Pedodontics and Preventive Dentistry)

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751