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Study suggests excess vitamin B3 could increase heart disease risk - Video

Published On 2024-02-24T04:30:22+05:30  |  Updated On 24 Feb 2024 2:15 PM IST
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Overview

The team, led by Stanley Hazen, M.D., Ph.D., from Cleveland Clinic have discovered a link between 4PY, a breakdown product from excess niacin, and heart disease.

The study, published in Nature Medicine, details genetic links between 4PY and vascular inflammation. The findings provide a foundation for potential newinterventions and therapeutics to reduce or prevent that inflammation.

Niacin, also known as vitamin B-3, is one of the eight B vitamins essential for converting food into energy and maintaining healthy skin and nervous system function. Since the body cannot produce niacin on its own, it must be obtained from dietary sources or supplements. Tryptophan, found in animal products, is converted into niacin by the body. Any excess niacin not utilized by the body is eliminated through urine, as it is not stored.

Excessive niacin can lead to an increase in certain blood fats, which may contribute to heart disease risk. Additionally, high doses of niacin can cause flushing, which may worsen existing cardiovascular conditions.

For the study, Dr. Hazen and his team studied the fasting plasma from about 1,100 people with stable cardiac health. Upon analysis, researchers discovered that higher circulating levels of N1-methyl-4-pyridone-3-carboxamide, or 4PY, were strongly associated with the development of a heart attack, stroke, or other unhealthy cardiac events.

The findings suggested that 4PY directly triggers vascular inflammation which damages blood vessels and can lead to atherosclerosis over time.

“The compound 4PY was identified that is linked to future CVD events” said Dr. Hazen. “We then performed pre clinical studies (animal model) and cell-based studies — all of which showed this compound contributes to vascular inflammation. 4PY, it turns out, is a breakdown product made from excess niacin.”

“Our studies found high levels of 4PY in the blood predict future cardiac disease. These new studies help identify a new pathway that contributes to heart disease,” concluded Dr. Hazen.

Reference: Cleveland Clinic

Speakers

Anshika Mishra

Anshika Mishra is a dedicated scholar pursuing a Masters in Biotechnology, driven by a profound passion for exploring the intersection of science and healthcare. Having embarked on this academic journey with a passion to make meaningful contributions to the medical field, Anshika joined Medical Dialogues in 2023 to further delve into the realms of healthcare journalism.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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