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Underlying genetic risks for a type of heart attack largely affecting younger women revealed - Video

Published On 2023-05-30T09:30:17+05:30  |  Updated On 30 May 2023 9:30 AM IST
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Overview

Research led by the1 National Institute for Health and Care Research,2 Leicester Biomedical Research Centre and3 Universite Paris Cite, and supported by worldwide partners has identified new genes that are associated with an increased risk of a type of heart attack primarily affecting 4young to middle-aged women.

5SCAD – or Spontaneous Coronary Artery Dissection - is when a bruise or bleed occurs in the wall of a coronary artery, cutting off the blood to part of the heart. This leads to a heart attack. Unlike other types of heart attack, SCAD is most common in women under the age of 60 and is a leading cause of6 heart attacks around the time of pregnancy. Furthermore, people who have had a SCAD tend to be generally healthy and SCAD can sometimes happen more than once.

The researchers present a genome-wide association meta-analysis involving a total of 1,917 cases of SCAD and 9,292 controls from European ancestry. They found 16 genes that increased the risk of a SCAD. The identified genes are involved in processes that determine how the cells and connective tissue hold together, and also how the blood clots when bleeding occurs in tissues.

Interestingly, the researchers found that, while many genes linked to a higher risk of SCAD are shared with risk genes for7 conventional coronary artery disease (CAD), they have an opposite effect. This means patients with a SCAD have some genetic protection from the risk of CAD, and is further evidence that these diseases are very different. The only shared risk factor appeared to be8 genetically elevated blood pressure.

Reference:

Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation,Nature Genetics,DOI 10.1038/s41588-023-01410-1

Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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