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Unlocking the healing power of oral keratinocytes - Video

Published On 2023-07-01T09:30:48+05:30  |  Updated On 1 July 2023 9:30 AM IST
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Overview

Japanese scientists have made significant progress in understanding the signals involved in regulating oral keratinocyte cell motility and proliferative capacity, offering new insights into potential pharmacological manipulation for regenerative medicine.

Professor Kenji Izumi and his team examined the impact of growth supplements on oral keratinocyte behavior. They discovered that EGF in the supplement significantly affected cell motility and proliferation. This finding indicates the crucial role of EGF in regulating the behavior and quality of oral keratinocytes.

Interestingly, the study also revealed that the STAT3 and ERK1/2 pathways, previously thought to be major contributors to oral keratinocyte behavior, showed only minor effects.

Moreover, the researchers observed reciprocal interaction between Src and EGFR in oral keratinocytes. The activation of Src, a non-receptor tyrosine kinase, appeared to transduce signals from various receptors to internal signaling pathways, affecting cellular events such as survival, adhesion, proliferation, and migration. This interaction between Src and EGFR suggests potential upstream signal transduction from Src to the EGF/EGFR axis in oral keratinocytes.

The study investigated the connection between EGFR signaling and E-cadherin expression, a crucial molecule for cell adhesion. The researchers discovered that EGFR and Src suppressed E-cadherin expression, thereby affecting cell migration.

Reference: The EGF/EGFR axis and its downstream signaling pathways regulate the motility and proliferation of cultured oral keratinocytes, FEBS Open Bio, DOI 10.1002/2211-5463.13653

Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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