Are You A Night Owl? You May Face 50% More Likelihood of Developing Diabetes: EASD 2024 - Video

Night owls have a higher BMI, larger waists, more hidden body fat and are almost 50% more likely to develop type 2 diabetes (T2D) than those who go to bed earlier(14), new research presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Madrid, Spain, has found.

Lead researcher Dr Jeroen van der Velde, of Leiden University Medical Centre, Leiden, Netherlands, says: “Previous studies have indicated that a late chronotype – preferring to go to bed late and wake up later – is associated with an unhealthy lifestyle. Late chronotypes are more likely to smoke or have an unhealthy diet, for example, and it has been suggested this is why they are higher risk of obesity and metabolic disorders including type 2 diabetes.

“However, we believe that lifestyle cannot fully explain the relationship between a late chronotype and metabolic disorders. In addition, while it is known that a late chronotype is associated with high BMI, it isn’t clear to what extent chronotype affects body fat distribution.”(15)

To find out more, Dr van der Velde and colleagues studied the association between sleep timing, T2D and body fat distribution(16) in more than 5,000 individuals, as part of the Netherlands Epidemiology of Obesity study, an ongoing study into the influence of body fat on disease.

The analysis involved participants (54% female) with a mean age of 56 years and mean BMI of 30 kg/m2.

Participants filled in a questionnaire their typical bed and waking times and from this midpoint of sleep (MPS)(17) was calculated.

The participants were then divided into three groups: early chronotype (the 20% of participants with the earliest MPS), late chronotype (the 20% of participants with the latest MPS) and intermediate chronotype (the remaining 60% of participants).

BMI and waist circumference were measured in all participants(18). Visceral fat and liver fat were measured in 1,526 participants, using MRI scans and MR spectroscopy, respectively.

The participants were followed-up for a median of 6.6 years, during which 225 were diagnosed with T2D.

The results, which were adjusted for age, sex, education, total body fat and a range of lifestyle factors (physical activity, diet quality, alcohol intake, smoking and sleep quality and duration), showed that compared with an intermediate chronotype, participants with a late chronotype had a 46% higher risk of T2D.(19)

This suggests that the increased risk of T2D in late chronotypes can’t be explained by lifestyle alone.

“We believe that other mechanisms are also at play,” says Dr van der Velde. “A likely explanation is that the circadian rhythm or body clock in late chronotypes is out of sync with the work and social schedules followed by society. This can lead to circadian misalignment, which we know can lead to metabolic disturbances and ultimately type 2 diabetes.”(15)

Reference: van der Velde, J. H. P., Rutters, F., Rosendaal, F. R., Lamb, H. J., Kalsbeek, A., & de Mutsert, R. (2024). Associations between chronotype, waist circumference, visceral fat, liver fat, and incidence of type 2 diabetes. Abstract presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD), Madrid, Spain.