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Researchers uncover surprising side effects of common diabetes drug Metformin - Video

Published On 2023-09-19T09:00:19+05:30  |  Updated On 19 Sept 2023 9:00 AM IST
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Overview

Metformin, a well-established diabetes medication, has revealed unexpected benefits beyond blood sugar control. Researchers at the University of Utah Health have discovered its potential to combat muscle atrophy and fibrosis by targeting senescent cells, often referred to as 'zombie-like cells,' which can hinder muscle function. Senescent cells release inflammatory factors linked to tissue fibrosis, a condition characterized by tissue hardening and scarring.

The research team aimed to identify an effective therapeutic approach that could address both disuse-related muscle atrophy and promote muscle recovery. Pre-clinical studies had already demonstrated Metformin's anti-senescent properties.

To evaluate this intervention in humans, the researchers enlisted 20 healthy older adults, both male and female, for a multi-week study. Participants underwent a muscle biopsy and MRI before the intervention, which involved a five-day bed rest period. During a two-week run-in phase, one group of 10 received Metformin, while the other 10 received placebo pills. Subsequently, each group continued their respective treatment—either placebo or Metformin—during the bed rest phase. After the bed rest, participants received another muscle biopsy and MRI, then ceased treatments.

The researchers found that when participants took Metformin during bed rest, they had less muscle atrophy. During the recovery period, their muscles also had less fibrosis or excessive collagen. That build-up can make it harder for the muscle to properly function.

Reference: Disuse-induced muscle fibrosis, cellular senescence, and senescence-associated secretory phenotype in older adults are alleviated during re-ambulation with metformin pre-treatment” by Jonathan J. Petrocelli, Alec I. McKenzie, Naomi M. M. P. de Hart, Paul T. Reidy, Ziad S. Mahmassani, Alexander R. Keeble, Katie L. Kaput, Matthew P. Wahl, Matthew T. Rondina, Robin L. Marcus, Corrine K. Welt, William L. Holland, Katsuhiko Funai, Christopher S. Fry and Micah J. Drummond, 24 July 2023, Aging Cell, DOI: 10.1111/acel.13936

Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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