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'Twincretin' Tirzepatide Recieves FDA Approval for Type 2 Diabetes - Video

Published On 2022-05-18T10:30:34+05:30  |  Updated On 18 May 2022 10:30 AM IST
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Overview

The "Twincretin" era for treating patients with type 2 diabetes has begun, with the US Food and Drug Administration's (FDA's) approval of tirzepatide for this indication, making it the first approved agent that works as a dual agonist for the two principal human incretins.

the FDA stated that Tirzepatide represents an important advance in the treatment of type 2 diabetes, Lipid Disorders, and Obesity. That advance is based on tirzepatide's engineering, which gives it agonist properties for both the glucagon-like peptide-1 (GLP-1) receptor, as well as the glucose-dependent insulinotropic polypeptide (GIP).

The FDA's approved label includes all three dosages of tirzepatide that underwent testing in the pivotal trials: 5 mg, 10 mg, and 15 mg, each delivered by subcutaneous injection once a week. Also approved was the 2.5 mg/week dose used when starting a patient on the agent. Gradual up-titration appears to minimize possible gastrointestinal adverse effects during initial tirzepatide use.

Tirzepatide, to be marketed by Lilly as Mounjaro, and hit the US market with much anticipation, based on results from five pivotal trials, all reported during the past year or so, that established the drug's unprecedented efficacy for reducing A1c levels as well as triggering significant weight loss in most patients with a generally benign safety profile.

Given its outstanding efficacy at both lowering glucose and weight, researchers expect tirzepatide to have quick uptake among patients with diabetes. The only limiting factor will be cost, highlighting the major stumbling block that could limit tirzepatide's uptake.


Speakers

Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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