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Yet another study reaffirms direct link between depression and type 2 diabetes development - Video

Published On 2023-09-13T09:30:49+05:30  |  Updated On 29 Jan 2024 4:45 PM IST
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Overview

A causal positive association from depression to type 2 diabetes, with evidence of mediation by BMI was found in a recent study published in Diabetes Care Journal, a peer-reviewed medical journal by the American Diabetes Association. The researchers also performed a multi-phenotype GWAS (MP-GWAS) of the two diseases, highlighting seven shared loci that target nearby genes in several target tissues.

Type 2 diabetes is a disease characterized by chronic hyperglycemia, while depression is its frequent comorbidity, potentially because of shared risk factors. It has been shown that depression, even at subclinical levels, increases the risk of incident type 2 diabetes by 25–60% . whereas others have shown that type 2 diabetes increases the risk of depression by 40–60%.

Depression is a common comorbidity of type 2 diabetes. The team assessed the causal relationships and shared genetics between them.

To identify shared genetics, the study authors performed; 1) genome-wide association studies (GWAS) separately and 2) multiphenotype GWAS (MP-GWAS) of type 2 diabetes (19,344 case subjects, 463,641 control subjects) and depression using major depressive disorder (MDD) and self-reported depressive symptoms in the UK Biobank. They analyzed expression quantitative trait locus (eQTL) data from public databases to identify target genes in relevant tissues.

The results highlighted the importance to prevent type 2 diabetes at the onset of depressive symptoms and the need to maintain a healthy weight in the context of its effect on depression and type 2 diabetes comorbidity.

Reference: Jared G. Maina, Zhanna Balkhiyarova, Arie Nouwen, Igor Pupko, Anna Ulrich, Mathilde Boissel, Amélie Bonnefond, Philippe Froguel, Amna Khamis, Inga Prokopenko, Marika Kaakinen; Bidirectional Mendelian Randomization and Multiphenotype GWAS Show Causality and Shared Pathophysiology Between Depression and Type 2 Diabetes. Diabetes Care 1 September 2023; 46 (9): 1707–1714. (https://doi.org/10.2337/dc22-2373)

Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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