Weight loss may stabilize neuropathy, according to a recent study published in the Obesity. In the study, after 2 years, successful dietary weight loss in those with severe obesity lead to stable neuropathy as measured by our primary outcome (intraepidermal nerve fiber density).
Neuropathy is a highly prevalent condition that results in pain, falls, and lower quality of life. Although diabetes has long been known to be the leading cause of neuropathy, obesity has recently emerged as an important risk factor. Furthermore, obesity is likely sufficient to cause neuropathy even in those with normal glucose control. In addition to hyperglycemia and obesity, other individual components of metabolic syndrome (hypertension, hypertriglyceridemia, and low high-density lipoprotein [HDL] cholesterol) have also been shown to be associated with neuropathy. Unfortunately, despite multiple potentially modifiable risk factors, the only established disease-modifying therapy for neuropathy is glycemic control, which prevents neuropathy to a much larger degree in type 1 than in type 2 diabetes.
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