Genes involved in Crohn's disease - Video
|
Overview
An international consortium of researchers has identified genetic variants in 10 genes that elevate a person's susceptibility to Crohn's disease, a form of inflammatory bowel disease. These discoveries highlight the causal role of mesenchymal cells in intestinal inflammation, helping to zero in on the genetic roots of inflammatory bowel disease and providing better data with which to develop the next generation of treatments.
In this study, researchers at the Welcome Sanger Institute and the Broad Institute set out to identify rare genetic variants within protein-coding genes that are associated with Crohn's disease susceptibility. They performed exome sequencing on around 30,000 patients with Crohn's and compared these to exome sequences from around 80,000 individuals without the condition. This identified genetic variation within six genes in regions of the genome that had not been previously connected to Crohn's disease. Several of these genes are known to play important roles in a type of stem cell in the gut called mesenchymal cells suggesting that disruption of these cells contributes to the initiation and maintenance of intestinal inflammation.
Ref:
Venkataraman and Kai Yuan et al. (2022). Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility,Nature Genetics,10.1038/s41588-022-01156-2
Speakers
Isra Zaman
B.Sc Life Sciences, M.Sc Biotechnology, B.Ed
Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751