Research reveals people with this blood type may have a higher fatal liver disease risk - Video

Your blood type may reveal more than just transfusion compatibility-it could signal your risk for certain liver diseases. A new study published in Frontiers in Medicine shows that people with blood type A are more prone to autoimmune liver diseases, where the immune system mistakenly attacks the liver, potentially causing long-term damage. Autoimmune hepatitis, which attacks liver cells, is especially linked to blood type A.

Autoimmune hepatitis is a condition where the body’s immune system mistakenly attacks its own liver cells, causing inflammation and damage. Normally, the immune system defends against harmful invaders like viruses and bacteria, but in this disorder, it targets healthy liver tissue instead. This ongoing attack leads to swelling and irritation, which, if left untreated, can cause scarring and eventually liver failure.

On the other hand, individuals with blood type B appear to have a lower risk, particularly for primary biliary cholangitis (PBC), a chronic disease that damages bile ducts and can lead to liver failure. The study analyzed data from over 1,200 people, including 114 patients with autoimmune liver conditions, finding the highest incidence among blood type A, followed by O, B, and AB groups. Blood type is determined by specific antigens on red blood cells, dividing people into A, B, AB, and O groups, each with positive or negative subtypes.

While having blood type A doesn’t guarantee liver disease, it is a factor to consider if you experience unexplained symptoms like fatigue or joint pain. Experts recommend regular liver function check-ups, a healthy diet rich in whole grains, fruits, vegetables, legumes, nuts, and unsaturated fats like olive oil, along with avoiding alcohol to minimize liver damage—especially in PBC. Calcium and vitamin D supplements can support bone health, since liver disease can increase osteoporosis risk. Smoking cessation and physical activity are also advised to maintain overall liver and bone well-being.

This study sheds light on the complex relationship between genetics and liver health, encouraging personalized monitoring and lifestyle adjustments to protect those at higher risk. More research is needed to fully understand these links across diverse populations.

REFERENCE: Hong,Yi; Mu,Shijie; Wang,Lin; Association between ABO blood group system and autoimmune liver disease; Frontiers in Medicine; 2025; Volume 12 – 2025; https://doi.org/10.3389/fmed.2025.1696577