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Study of male contraceptive pills called progestogenic androgens shows promise - Video
Overview
Two experimental male contraceptive pills appear to effectively lower testosterone without causing unacceptable side effects, according to a new study that will be presented today at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Ga.
The drugs, called DMAU and 11β-MNTDC, are part of a class of drugs called progestogenic androgens. These drugs suppress testosterone, which lowers sperm count. Lowering testosterone levels normally leads to unpleasant side effects, but most of the men in the study were willing to continue using the drugs, suggesting the side effects were acceptable.
The study included 96 healthy male participants in two Phase 1 clinical trials. In each trial, the men were randomly assigned to receive two or four oral pills of active drug or placebo daily for 28 days. After seven days on the active drug, testosterone levels dropped below the normal range. In men taking the placebo, testosterone levels stayed within the normal range.
The study found that 75% of men who took the active drug said they would be willing to use it in the future, compared with 46.4% of those taking a placebo. Men who took the four-pill daily dose (400 milligrams) had lower levels of testosterone than those taking the two-pill, 200-milligram dose. There was no significant difference between the two active treatment groups in satisfaction with the drug, or willingness to use it in the future or recommend it to others.
Lead researcher Tamar Jacobsohn of the Contraceptive Development Program at the Eunice Kennedy Shriver National Institute of Child Health and Human Development said, "Male contraception options are currently restricted to vasectomy and condoms, and are thus extremely limited as compared to female options," He further added that development of an effective, reversible male contraceptive method will improve reproductive options for men and women, have a major impact on public health by decreasing unintended pregnancy, and allow men to have an increasingly active role in family planning.
MD had previously reported about a non-hormonal, oral contraceptive pill for males which had shown 99% efficacy in a previous study on mice as reported by scientists from the American Chemical Society.
Speakers
Isra Zaman
B.Sc Life Sciences, M.Sc Biotechnology, B.Ed