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Two antiseptics prevent infections equally well after fracture surgery - Video

Published On 2022-10-17T09:45:00+05:30  |  Updated On 17 Oct 2022 9:45 AM IST
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Overview

The study leaders from the University of Maryland School of Medicine (UMSOM) and McMaster University concluded that orthopedic surgeons could select either of the two solutions -- aqueous 10% povidone-iodine or aqueous 4% chlorhexidine gluconate - for infection prevention, based on a recent study.

The study, called Aqueous-PREP, was published in The Lancet and presented at the Orthopaedic Trauma Association meeting in Tampa, FL. Study participants were enrolled from a total of 14 hospitals, including the University of Maryland Medical Center (UMMC), as well as other facilities in the U.S., Canada, and Spain.

"Many surgeons prefer to use povidone-iodine skin preparation for open fractures because of its wide availability as an effective aqueous solution," said study co-principal investigator Gerard Slobogean, MD, MPH, Associate Professor of Orthopedics at UMSOM and an orthopedic trauma surgeon at the R Adams Cowley Shock Trauma Center at UMMC. "Our findings should reassure surgeons that either antiseptic solution is fine to use, and they can base their decision on product availability, cost, or patient contraindications," Dr. Slobogean added.

To conduct the trial, the researchers recruited patients with open fractures that required surgery at the 14 participating hospitals. Each hospital was randomly assigned to use one of the antiseptic formulations at the beginning of the three-year trial; then, each hospital alternated between the solutions every two months. This unique study design, known as a multiple period cluster randomized crossover trial, ensured that all the hospitals used both formulations equally and controlled for variations among hospitals that could have also affected post-surgical infection rates.

"Open fractures are often devastating injuries that can be challenging to study due to the severity of the injuries and their need for urgent surgery. Patient engagement and our novel study design were key to overcoming many of the logistical challenges," said Sheila Sprague, PhD, MSc, co-principal investigator of the trial and an Associate Professor and Research Director at McMaster University.

Jeff Wells, trial executive committee member and patient partner, agrees. "As a patient involved in the trial, it was my job to ensure that the voice of trauma patients was heard in the design, implementation, and dissemination of the trial. However, many months into the project, I learned that involving patients in study leadership was uncommon," Wells said.

Added Andrew Pollak, MD, the James Lawrence Kernan Professor and Chair of the Department of Orthopedics at UMSOM and Senior Vice President and Chief Clinical Officer for the 11-hospital University of Maryland Medical System (UMMS), "This is a landmark study with important clinical implications. The findings are not only relevant to the management of open fractures but might also apply to the surgical treatment of other traumatic wounds."

Aqueous-PREP is one of two trials being led by Dr. Slobogean and colleagues that are aimed at closing gaps in the medical literature on the most effective infection-control techniques in orthopedic surgery. The study designs follow a master protocol called PREP-IT (Program of Randomized Trials to Evaluate Pre-operative Antiseptic Skin Solutions in Orthopaedic Trauma) to test infection prevention techniques in trials that will provide crucial evidence to help guide surgical practices. The second study called PREPARE will evaluate the use of two alcohol-based antiseptic skin preparations in surgical patients with both open and closed lower extremity fractures.

"Extremity fractures and the challenging surgical site infections that result from them pose a significant healthcare burden on our nation," said Mark T. Gladwin, MD, Vice President for Medical Affairs, University of Maryland, Baltimore, and the John Z. and Akiko K. Bowers Distinguished Professor and Dean, University of Maryland School of Medicine. "The master protocol used in this study provides efficiencies in study design and data collection and could serve as an important model for future comparative effectiveness studies in the surgical field."

Ref:

Aqueous skin antisepsis before surgical fixation of open fractures (Aqueous-PREP): a multiple-period, cluster-randomised, crossover trial, The Lancet,DOI

10.1016/S0140-6736(22)01652-X

Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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