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WHO Announces Fourth HPV Vaccine for Use in Single Dose Schedule - Video

Published On 2024-10-08T08:30:00+05:30  |  Updated On 8 Oct 2024 2:28 PM IST
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Overview

WHO announced that a fourth WHO-prequalified human papillomavirus (HPV) vaccine product, Cecolin has been confirmed for use in a single-dose schedule. The decision is made based on new data on the product that fulfilled the criteria set out in the WHO’s 2022 recommendations for alternative, off-label use of HPV vaccines in single-dose schedules. This important milestone will contribute to improving the sustainable supply of HPV vaccines-allowing more girls to be reached with the vaccines that prevent cervical cancer.
“Unlike most other cancers, we can eliminate cervical cancer, along with its painful inequities,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “By adding another option for a one-dose HPV vaccination schedule, we have taken another step closer to consigning cervical cancer to history.”
More than 95% of the 660,000 cervical cancer cases occurring globally each year are caused by HPV. Every two minutes, a woman dies from this preventable disease globally, and 90% of these deaths occur in low- and middle-income countries. Of the 20 hardest hit countries by cervical cancer 19 are in Africa.
HPV vaccine introductions have been hampered by global supply shortages since 2018 and production challenges encountered by one of the manufacturers earlier this year led to further shortfalls, potentially impacting millions of girls in need of HPV vaccines in Africa and Asia.
“Having 90% of girls fully vaccinated with the HPV vaccine by 15 years of age is the target for the first pillar of the WHO global strategy for cervical cancer elimination,” said Dr Kate O'Brien, Director of the Department of Immunization, Vaccines and Biologicals at WHO. “Given the continuing supply challenges, this addition of single-dose vaccine product means countries will have a greater choice of vaccines to reach more girls.”
A growing number of vaccine products initially prequalified for use in a 2-dose schedule can now be used in a single-dose schedule. The single-dose use indication for this additional vaccine, Cecolin®, is incorporated into the second edition of WHO’s technical document on considerations for HPV vaccine product choice. Like for other medications and vaccines, when there is data to support modified use, guided by a clear public health benefit, public health advisory bodies can recommend "off-label” use, until a manufacturer adds this modified use to their label.
A further piece of good news is the WHO prequalification on 2 August 2024, of an additional HPV vaccine, Walrinvax®, making it the fifth product available on the global market. This will contribute to a more sustainable supply of HPV vaccines, enabling more girls to receive the vaccine. Walrinvax® is prequalified with a two-dose schedule. Further data will be needed to assess if this vaccine can be recommended for single-dose schedule in the future.

Speakers

Dr. Bhumika Maikhuri

BDS, MDS

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