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Study finds parathyroidectomy not effective on kidney function in older adults with hyperparathyroidism - Video

Published On 2023-04-12T09:15:52+05:30  |  Updated On 14 April 2023 10:40 AM IST
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Overview

Primary hyperparathyroidism is a common endocrine disorder associated with an increased risk for chronic kidney disease (CKD). The only treatment is surgical removal of one or more abnormal parathyroid glands (parathyroidectomy). Current guidelines recommend parathyroidectomy in patients with primary hyperparathyroidism and CKD, in part to mitigate the risk for and effects of CKD progression. However, there are limited data documenting the association of parathyroidectomy with long-term kidney function to support this recommendation.

An emulated randomized trial performed using observational data from more than 43,000 adults with primary hyperparathyroidism found that parathyroidectomy had no estimated effect on long-term kidney function in older adults when compared to observation. However, early parathyroidectomy may preserve kidney function in patients younger than 60 years of age with primary hyperparathyroidism. The study is published in Annals of Internal Medicine.

Researchers from the Stanford University School of Medicine studied 43,697 adults diagnosed with primary hyperthyroidism to compare the incidence of a sustained decline in estimated glomerular filtration rate (eGFR) of at least 50 percent for those treated with parathyroidectomy versus nonoperative management. The researchers found that the weighted cumulative incidence of a sustained eGFR decline of at least 50 percent was 5.1 percent at 5 years, regardless of how primary hyperparathyroidism was managed. In the overall cohort, there was no difference in the adjusted rate of a sustained decline in eGFR among patients treated with parathyroidectomy versus nonoperative management. However, subgroup analyses indicated that patients younger than 60 years treated with early parathyroidectomy were more likely to preserve long-term kidney function.

According to the authors, these findings suggest that preservation of kidney function should not be a primary consideration when making treatment decisions about parathyroidectomy in older adults with primary hyperparathyroidism and that focus on fracture risk and quality of life is more important in this group. However, clinicians should discuss the potential benefit of early parathyroidectomy to reduce the risk for CKD and associated complications in patients younger than 60 years who are diagnosed with primary hyperparathyroidism.

Reference:

AMERICAN COLLEGE OF PHYSICIANS,Annals of Internal Medicine, DOI10.7326/M22-2222

Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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