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ADHD drugs might also treat Alzheimer's disease - Video

Published On 8 July 2022 4:00 AM  |  Updated On 8 July 2022 4:00 AM
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Overview

There is "good evidence" that drugs to treat attention deficit hyperactivity disorder (ADHD) might also successfully treat key aspects of Alzheimer's disease, finds a pooled data analysis of the available research, published online in the Journal of Neurology Neurosurgery & Psychiatry.

Noradrenergic disruption occurs early in Alzheimer's disease and contributes to the cognitive and neuropsychiatric symptoms that characterise the condition, suggesting that the noradrenergic system would be a good target for drug treatment.

The researchers therefore looked for clinical trials published between 1980 and 2021 in which noradrenergic drugs, such as atomoxetine, methylphenidate, and guanfacine, had been used to potentially improve cognitive and/or neuropsychiatric symptoms in people with neurodegenerative disease.

They included a total of 19 randomised controlled trials focusing on Alzheimer's disease and mild cognitive impairment, involving 1811 patients: six of these trials were judged to be 'good' quality, seven as 'fair', and six as 'poor'. The results of 10 of these trials, involving 1300 patients, were pooled for global cognition-orientation/attention, memory, verbal fluency, language and visuospatial ability.

This showed a small, but significant, positive effect of noradrenergic drugs on overall cognition, as measured by the Mini-Mental State Exam or the Alzheimer's Disease Assessment Scale. The results of 8 clinical trials, involving 425 patients, were then pooled for behaviour and neuropsychiatric symptoms, agitation and apathy. And this showed a large positive effect of noradrenergic drugs on apathy, even after removing outliers to account for differences in trial design and intended outcomes.

Repurposing of established noradrenergic drugs is most likely to offer effective treatment in Alzheimer's disease for general cognition and apathy, ended the researchers.

Reference: "Cognitive and neuropsychiatric effects of noradrenergic treatment in Alzheimer's disease: systematic review and meta-analysis" BMJ- Journal of Neurology, Neurosurgery & Psychiatry. DOI:10.1136/jnnp-2022-329136

Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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