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Distinct patterns of pre-existing brain health characteristics in stroke patients identified - Video

Published On 2023-05-29T09:30:00+05:30  |  Updated On 29 May 2023 9:30 AM IST
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Overview

Extensive research has helped pinpoint risk factors for initial stroke, but there is limited understanding about what the brains of stroke patients look like on a population level, according to UC’s Achala Vagal, MD, professor of neuroradiology.

University of Cincinnati researchers are presenting abstracts at the European Stroke Organization Conference (ESOC) 2023, May 24-26 in Munich, Germany, including the results of the first large-scale assessment of radiological brain health in stroke patients in a population.

“Imaging can be an objective manifestation of the presence and severity of clinical factors such as diabetes, hypertension, high cholesterol and kidney failure,” she said. “However, the majority of the large epidemiological studies of brain health have been performed in stroke-free subjects.”

Vagal was a co-principal investigator on the Assessing Population-based Radiological brain health in Stroke Epidemiology (APRISE) study that gained new information from neuroimaging results of stroke patients.

The research team analyzed all available clinical imaging data from nearly 3,500 patients who had a stroke in the Greater Cincinnati/Northern Kentucky region in 2015, assessing the imaging for signs of small vessel disease in the brain in the form of previous injury, microbleeds, white matter disease (wearing away of tissue) or brain atrophy, among other observations.

Vagal said the team identified three distinct clusters of observable imaging characteristics that were each associated with a specific set of clinical variables.

“This can help us understand the biology of preexisting brain health in stroke patients and help guide future interventions,” she said. “We expected all the imaging parameters of brain health due to small vessel disease to be closely clustered, but we found a lack of clustering of microbleeds with white matter disease.”

With the knowledge gained from the study, Vagal said the team is now using the brain health imaging data to build a prediction model of recurrent stroke.

“Such large-scale characterization of preexisting brain health is helpful to identify novel observable characteristics which can guide further studies,” she said.

Reference:

ACHALA VAGAL et al,“Radiological Phenotypes of Brain Health in a Stroke Population: Primary Results of the Assessing Population-Based Radiological Brain Health in Stroke Epidemiology (APRISE) Study''UNIVERSITY OF CINCINNATI

Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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