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Methanol-induced parkinsonism and cerebral vasculopathy due to perfume inhalation - Video

Published On 2022-05-31T09:30:07+05:30  |  Updated On 31 May 2022 9:30 AM IST
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Overview

The most common cause of methanol poisoning is through ingestion of adulterated alcohol; however, other routes of poisoning may also occur including cutaneous exposure and, rarely, inhalation. A case report in BMJ Neurol Open represents an unusual presentation of incidental methanol intoxication through inadvertent inhalation while manufacturing homemade perfume. It also highlights an additional, yet unrecognised finding of cerebral artery spasms as a squeal of methanol poisoning.

A woman in her 30s living in a rural area of Saudi Arabia was referred to our tertiary care facility for the management of sudden vision loss and parkinsonism. The patient makes a living by manufacturing local perfumes at home, and to compensate for increased demand for her product, she admitted to using adulterated alcohol from a different local vendor. She was admitted to her local hospital as a case of encephalopathy with optic neuritis, and she required intubation.

She was misdiagnosed as having autoimmune encephalitis, for which she received a course of pulse methyl prednisolone followed by intravenous immunoglobulin G (IVIG). The brain MRI showed bilateral and symmetrical areas of bright T2 sight. The frontal and occipital lobes showed bilateral, symmetrical, subcortical, hyperintense T2 signals with heterogeneous contrast enhancements in addition to enhancement of the optic nerves bilaterally.

There was significant rigidity and bradykinesia. A sensory examination was unremarkable to all modalities as well as cerebellar examination. Her gait revealed a decreased arm swing bilaterally with a shuffling gait and mild postural instability. The estimated unified Parkinson's disease rating scale (UPDRS) III was 50.

The preliminary diagnosis was methanol toxicity due to the nature of her disease progression and typical radiological imaging. As the patient denied any history of alcohol intake, results showed to have found a high concentration of methyl alcohol. Symptomatic therapy consisting of carbidopa–levodopa and pramipexole was started with a gradual increase in the dosages. Parkinsonian symptoms resulting from methanol poisoning were managed by the use of dopaminergic agents, as was the case with the patient who showed a fair response to levodopa-carbidopa and pramipexole.

Speakers

Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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