Potential markers for alzheimer's disease: Plasma p-tau181/Aβ1-42 - Video

Published On 2022-03-28T18:30:20+05:30 | Updated On 28 March 2022 6:30 PM IST

Overview

Alzheimer's disease is thought to be caused by the abnormal build-up of proteins in and around brain cells. One of the proteins involved is called amyloid, deposits of which form plaques around brain cells. The other protein is called tau, deposits of which form tangles within brain cells. Tau proteins presence is considered to be a classic marker for detecting Alzheimers disease.

In Alzheimer's disease, plasma Aβ1-42 and p-tau predict high amyloid status from Aβ-PET and is proving to be the be potential markers. A recent study in MedRxiv by Christopher Fowler and team found that Plasma p-tau181/Aβ1-42 ratio is a potential predictor of both Aβ-PET status and cognitive decline, demonstrating potential as both a diagnostic aid and as a screening and prognostic assay for preclinical Alzheimer's disease trials.

Speakers

Dr. Nandita Mohan

BDS, MDS( Pedodontics and Preventive Dentistry)

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751