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Predicting Alzheimes dementia in oldest of the old - Video

Published On 2023-12-26T09:00:00+05:30  |  Updated On 26 Dec 2023 3:13 PM IST
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Overview

A new study indicates that severity of amyloid deposition in the brain-not just age-may be key to determining who will benefit from new anti-amyloid therapies to delay the progression of Alzheimer’s disease.

University of Pittsburgh clinicians and scientists report that the accumulation of toxic amyloid beta clumps that signal Alzheimer’s disease pathology accelerates in old age but the baseline amyloid burden and the overall brain health going into this acceleration are more powerful predictors of who is most likely to progress to Alzheimer’s. The paper was published today in Neurology, the medical journal of the American Academy of Neurology.

The presence and the overall quantity and distribution of amyloid beta, or A-beta, clumps in the brain are some of the most common neuropathologies associated with Alzheimer’s. Yet, while people who are 80 and older have the highest prevalence of Alzheimer’s-associated dementias, most studies that measured A-beta burden in the brain using imaging techniques have focused on younger populations. As such, the connection between A-beta and dementia in the oldest of the old have remained unclear.

“Our findings are consistent with studies showing that the amyloid accumulation in the brain takes decades to develop, and occurs in the context of other brain pathologies, specifically small vessel disease,” said Lopez, who also directs Pitt’s Alzheimer's Disease Research Center. “Whether there is a vascular process that occurs in parallel to the A-beta deposition could not be examined in this study. However, understanding of the timing of the presence of these pathologies will be critical for the implementation of future primary prevention therapies.”

Reference: Predicting Alzheimer’s dementia in oldest of the old, UNIVERSITY OF PITTSBURGH, Neurology

Speakers

Anshika Mishra

Anshika Mishra is a dedicated scholar pursuing a Masters in Biotechnology, driven by a profound passion for exploring the intersection of science and healthcare. Having embarked on this academic journey with a passion to make meaningful contributions to the medical field, Anshika joined Medical Dialogues in 2023 to further delve into the realms of healthcare journalism.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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