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TDP-43 in nerve bundles- a novel diagnostic biomarker for Amyotrophic Lateral Sclerosis

Published On 2022-05-28T10:15:03+05:30  |  Updated On 2022-05-28T13:40:15+05:30
TDP-43 in nerve bundles- a novel diagnostic biomarker for Amyotrophic Lateral Sclerosis

Overview

A dual case-control study of 10 autopsied patients with sporadic amyotrophic lateral sclerosis (SALS) were confirmed to have phosphorylated transactive response DNA-binding protein 43 (pTDP- 43)–positive axons in intramuscular nerve bundles. The findings of the study are published in JAMA Open Network.

The study comprised of two parts, a postmortem case-control study and a retrospective population-based cohort study with a minimum of 1 year of follow-up. The postmortem study included patients with sporadic ALS (SALS) with TDP-43 pathology and control patients with non-ALS disease.

It was seen that a total of 10 patients with autopsy-confirmed Sporadic ALS exhibited axonal phosphorylated TDP-43 (pTDP-43)–positive accumulations in intramuscular nerve bundles. Among the 114 patients, 62.3% exhibited intramuscular nerve bundles.

Among those who exhibited phosphorylated transactive response DNA-binding protein 43-positive intramuscular nerve bundles, 33 patients were later diagnosed with the condition. Among those without evident nerve bundles, 3 were later diagnosed with ALS.

Researchers hence, concluded that axonal phosphorylated transactive response DNA-binding protein 43 accumulations may be characteristic for patients with ALS and that it can be a novel diagnostic biomarker for ALS.

Speakers

Dr. Nandita Mohan

BDS, MDS( Pedodontics and Preventive Dentistry)

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751
TDP-43 Amyotrophic Sclerosis non-ALS disease intramuscular nerve biomarker JAMA Open Network nerves 
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