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A machine learning model to predict immunotherapy response in cancer patients - Video

Published On 2022-07-12T09:45:18+05:30  |  Updated On 12 July 2022 9:45 AM IST
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Overview

The recently developed immune checkpoint inhibitor has considerably improved the survival rate of patients with cancer. However, the problem with cancer immunotherapy is that only approximately 30% of cancer patients receive benefits from its therapeutic effect, and the current diagnostic techniques do not accurately predict the patient's response to the treatment.

Under this circumstance, the research team led by Professor Sanguk Kim (Department of Life Sciences) at POSTECH is gaining attention as they have improved the accuracy of predicting patient response to immune checkpoint inhibitors (ICIs) by using network-based machine learning. The research team discovered new network-based biomarkers by analyzing the clinical results of more than 700 patients with three different cancers (melanoma, gastric cancer, and bladder cancer) and the transcriptome data of the patients' cancer tissues.

By utilizing the network-based biomarkers, the team successfully developed artificial intelligence that could predict the response to anticancer treatment. The team further proved that the treatment response prediction based on the newly discovered biomarkers was superior to that based on conventional anticancer treatment biomarkers including immunotherapy targets and tumor microenvironment markers.

This study helps detect patients who will respond to immunotherapy in advance and establish treatment plans, resulting in customized precision medicine with more patients to benefit from cancer treatments. Supported by the POSTECH Medical Device Innovation Center, the Graduate School of Artificial Intelligence, and Immuno Biome Inc, this study was recently published in Nature Communications, an international peer-reviewed journal.

Reference: Kong, J., Ha, D., Lee, J. et al. Network-based machine learning approach to predict immunotherapy response in cancer patients. Nat Commun 13, 3703 (2022). https://doi.org/10.1038/s41467-022-31535-6

Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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