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Bladder Cancer: New Treatment Approach May Help Patients Avoid Life-Altering Surgery - Video

Published On 2023-10-12T09:00:33+05:30  |  Updated On 12 Oct 2023 9:00 AM IST
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Overview

A combination treatment approach with gemcitabine, cisplatin, and nivolumab in muscle-invasive bladder cancer (MIBC) patients resulted in a clinical complete response (cCR) rate of 43%, enabling bladder preservation without immediate cystectomy. The study published in Nature Medicine revealed a cCR rate of 43%, with 97% positive predictive value for cCR, signaling a potential paradigm shift in the treatment of MIBC.

While cystectomy is a major surgery, until now it has been the best chance for patients with MIBC to be cured of the cancer. MIBC is often located in a deep part of the bladder. It can be difficult to completely remove the cancer without removing the entire bladder.

In addition to these findings, the study shed light on the safety profile of this approach, with common adverse events primarily consisting of manageable side effects such as fatigue, anemia, neutropenia, and nausea. Importantly, the study also explored the role of specific genes and tumor mutational burden in predicting treatment outcomes.

Further analyses delved into peripheral blood mass cytometry and soluble protein analytes, revealing intriguing associations between the immune contexture and clinical outcomes. These findings emphasize the significance of personalized medicine and the potential to revolutionize MIBC treatment strategies, offering patients the opportunity for bladder preservation instead of radical surgery.

Ref: Galsky, M.D., Daneshmand, S., Izadmehr, S. et al. Gemcitabine and cisplatin plus nivolumab as organ-sparing treatment for muscle-invasive bladder cancer: a phase 2 trial. Nat Med (2023). https://doi.org/10.1038/s41591-023-02568-1

Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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