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Further hope for base-edited T-cell therapy to treat resistant leukaemia - Video

Published On 2023-06-16T09:00:11+05:30  |  Updated On 16 Jun 2023 3:12 PM IST
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Overview

Three young patients with relapsed T-cell leukemia have now been treated with base-edited T-cells, as part of a 'bench-to-bedside' collaboration between UCL and Great Ormond Street Hospital for Children (GOSH).

The data from the NHS clinical trial, shows how donor's CAR T cells were engineered using cutting edge gene editing technology to change single letters of their DNA code so they could fight leukemia.

The experience of using the cells in three patients is shared and includes 13-year-old Alyssa from Leicester, who last year was the first person in the world to be treated on the trial for T-cell acute lymphoblastic leukemia (T-ALL)*. This is a cancer of white blood cells and is usually treated with chemotherapy, but if it comes back, can be hard to clear.

Within four weeks of receiving the cells, Alyssa’s leukemia was undetectable and she went on to have a successful bone marrow transplant and is still well and at home almost a year later.

A second teenager cleared their leukemia within a similar time period and is now recovering at home after their transplant. Sadly, while a third child responded to the CAR T cell therapy, their course was complicated by serious infections and their family agreed with the clinical team to move to palliative care.

To generate banks of ‘universal’ anti-T-cell CAR T-cells for the study, the researchers used healthy donor T-cells, arranged by the Anthony Nolan registry. They then made changes to the cells using ‘base editing’, which works by chemically converting single nucleotide bases (letters of the DNA code) which carry instructions for a specific protein, in order to prevent them being produced.

Reference :Base-edited CAR T Cells for relapsed T-cell acute lymphoblastic leukemia ,New England Journal of Medicine

Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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