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Novel drug combination shows positive results for HPV-negative patients with advanced head and neck cancer - Video

Published On 2023-03-30T09:15:30+05:30  |  Updated On 30 March 2023 9:15 AM IST
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Overview

Head and neck cancer is a deadly form of cancer that arises in the lining of the mouth and throat. Worldwide more than 700,000 people were diagnosed with head and neck cancer in 2021. The disease is caused by the human papillomavirus (HPV) or environmental carcinogens, including the regular use of tobacco or alcohol. When the cancer comes back after curative treatment, patients have an overall survival of less than two years.

A new combination drug treatment showed promising results in patients with pan-refractory, recurrent/metastatic head and neck cancer, according to a study published today in the Journal of Clinical Oncology.

“Our study was conducted in patients with heavily resistant head and neck cancer, whose cancer had continued to grow in the face of all standard treatments including cetuximab,” Julie E. Bauman, M.D. the study’s lead author and professor of medicine at the George Washington University School of Medicine and Health Sciences, said. “In this pan-refractory population, the combination of drugs doubled the expected time until cancer progression.”

Bauman and colleagues’ randomized Phase II study used a new monoclonal antibody drug called ficlatuzumab. Patients were given ficlatuzumab alone or in combination with a standard drug known as cetuximab. Cetuximab already has U.S. Food and Drug Administration approval for head and neck cancer treatment.

Patients treated with both drugs also had a 19% overall response rate, meaning that 6 of 32 patients had at least 30% shrinkage of their tumors. These results were encouraging because the most realistic outcome for their treatment would have been to stabilize cancer growth for two months, Bauman said. Moreover, 2 of these patients had a complete response, losing all traces of their cancer after treatment.

“Unexpectedly, all responses occurred in patients with HPV-negative cancer,” Bauman said, translating to a 38% response rate in this subgroup. “This result was gratifying, as patients with HPV-negative disease have the worst overall survival. In this heavily pretreated group, we might have expected a 5% response rate.”

Bauman is currently working with a team of researchers to design a large, randomized, Phase III clinical trial to test the combination therapy against standard treatment in patients with advanced, HPV-negative head and neck cancer.

The study, “Randomized Phase II Trial of Ficlatuzumab with or without Cetuximab in Pan-Refractory, Recurrent/Metastatic Head and Neck Cancer,” was published online March 28 in the Journal of Clinical Oncology. The multicenter study was led by Bauman and conducted while she was a cancer researcher at the University of Arizona.

Reference:

Randomized Phase II Trial of Ficlatuzumab with or without Cetuximab in Pan-Refractory, Recurrent/Metastatic Head and Neck Cancer,Journal of Clinical Oncology

Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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