- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Novel Rectal Cancer Treatment: Claims Less Risk of Reoccurence and Avoid Surgery, Study Finds
Overview
A new treatment for advanced rectal cancer (LARC) called Total neoadjuvant treatment (TNT) has resurfaced and has proved successful enough to avoid surgery and reduce the risk of recurrence, according to a new study published in eClinical Medicine.
Total neoadjuvant treatment (TNT) combines short-course radiotherapy with several rounds of chemotherapy. A study conducted in Sweden revealed that this approach was twice as effective in shrinking tumours compared to earlier methods. Additionally, this treatment has the potential to decrease the necessity for complex bowel surgeries and the associated complications.
For the study, researchers tracked 273 patients with high-risk locally advanced rectal cancer (LARC) across 16 hospitals from July 2016 to June 2020, and an additional 189 patients at 18 hospitals (including the original 16) during the same timeframe. All patients underwent total neoadjuvant treatment (TNT). The study revealed that the proportion of patients with tumour disappearance increased from 14% to 28% compared to earlier treatment regimens, with no rise in recurrence rates.
The usual treatment for rectal cancer often involves over a month of radiotherapy or a mix of radiotherapy and chemotherapy. Surgery usually means removing part of the bowel, which can lead to issues with bowel control and the need for a stoma. Researchers noted that the new total neoadjuvant treatment (TNT) can directly target tumors and might reduce the need for this invasive surgery and its side effects.
Reference: Glimelius, B., Khan, T., Adolfsson, K., Angenete, E., Berglund, Ã…., & Bondef, K. (2024). Total neoadjuvant treatment using short-course radiotherapy and four CAPOX cycles in locally advanced rectal cancer with high-risk criteria for recurrence: A Swedish nationwide cohort study (LARCT-US). eClinicalMedicine. https://doi.org/10.1016/j.eclinm.2024.102771
Speakers
Dr. Garima Soni
BDS, MDS(orthodontics)