Menopausal Hormone Therapy Linked to Stronger Bones and Lower Osteoporosis Risk: Study - Video

For years, many women have been hesitant about menopause hormone therapy because of safety concerns. But new research suggests the treatment may also offer an important benefit-helping protect bones from thinning and reducing the risk of osteoporosis.

Women who use menopausal hormone therapy (MHT) may be significantly less likely to develop low bone mineral density than those who do not, according to a study presented at ENDO 2026, the Endocrine Society's annual meeting.

Researchers analyzed health data from 387 postmenopausal women who underwent bone density (DXA) scans between 2021 and 2025. About one-third of the participants were using menopausal hormone therapy, while the remaining two-thirds were not. The team compared rates of osteopenia and osteoporosis, conditions that weaken bones and increase fracture risk.

The findings showed that women taking hormone therapy had about a 69% lower risk of low bone mineral density in the spine and hip compared with non-users. This protective effect remained even after researchers accounted for factors such as age, years since menopause, vitamin D levels, smoking, and other medical conditions.

Healthy bones become especially important after menopause, when declining estrogen levels speed up bone loss and increase the risk of fractures, disability, and loss of independence.

The researchers say the findings could encourage doctors to weigh the benefits of hormone therapy more carefully, particularly for women in the early years after menopause who are also seeking relief from menopausal symptoms.

However, the study was retrospective, meaning it identified an association rather than proving cause and effect. More long-term research is needed to confirm the findings. Women should also remember that hormone therapy is not suitable for everyone, and decisions about its use should always be made with a healthcare professional after considering individual risks and benefits.

REFERENCE: Menopausal Hormone Therapy Reduces Risk of Low Bone Mineral Density by 69%; https://www.endocrine.org/news-and-advocacy/news-room/2026/diego-espinoza-peralta-press-release-endo-2026