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Protein that may help protect against osteoporosis identified

Published On 2023-08-14T09:15:39+05:30  |  Updated On 14 Aug 2023 9:25 AM GMT
Protein that may help protect against osteoporosis identified
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Overview

New research published in The FASEB Journal indicates that increasing the expression of a particular gene may help to prevent bone loss associated with postmenopausal osteoporosis. Postmenopausal osteoporosis is a medical condition characterized by a decrease in bone density and strength that occurs after menopause.

For the study, investigators examined which genes are involved in turning precursor cells called bone marrow–derived mesenchymal stem cells (BMSCs) into cells that play a crucial role in bone formation. The screen identified a gene that encodes high mobility group AT-hook 1 (Hmga1), a protein that controls the expression of a variety of other genes.

In experiments conducted in rats, expression of Hmga1 increased during bone formation but decreased when rats’ ovaries were removed (mimicking menopause). Treating ovariectomized rats with extra Hmga1 partially reversed bone loss in the animals.

“Our study demonstrated that Hmga1 prevents bone loss by promoting the osteogenic differentiation of BMSCs in osteoporosis rats, suggesting that Hmga1 could be an important therapeutic target for osteoporosis,” said corresponding author Yihe Hu.

Reference: Hmga1-overexpressing lentivirus 1 protects against osteoporosis by activating the Wnt/β-catenin 2 pathway in the osteogenic differentiation of BMSCs, The FASEB Journal; DOI 10.1096/fj.202300488R

Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.
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