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Race based spirometry equations may miss emphysema - Video

Published On 2022-07-20T09:15:43+05:30  |  Updated On 20 July 2022 9:15 AM IST
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Overview

A secondary data analysis of the CARDIA (Coronary Artery Risk Development In Young Adults) Lung study found that emphysema is often detectable on CT scan before spirometry findings become abnormal. The findings suggest that reliance on spirometry alone may result in the underrecognition of impaired respiratory health. Because the discrepancy is particularly present in Black men, this could exacerbate racial disparities. The analysis is published in Annals of Internal Medicine.

Spirometry is used in the assessment of COPD, but over reliance on spirometry may miss early signs of COPD and impaired respiratory health. Recent studies have shown that race-specific interpretations of spirometry may underestimate respiratory symptom burden and risk for death in Black adults.

Researchers from Northwestern University Feinberg School of Medicine conducted a secondary analysis of the CARDIA Lung study to determine the difference in emphysema prevalence between Black and White adults with normal spirometry results.

The study included 2,674 participants who received both a computed tomography (CT) scan and spirometry. The authors found that a substantial proportion of middle-aged adults with "normal" spirometry findings based on race-specific equations had emphysema on CT, and the trend was disproportionately seen among Black men even after adjusting for age and smoking. The use of race-neutral equations to interpret spirometry reduced the racial disparity in emphysema prevalence among those with "normal" results but did not eliminate it.

According to the authors, these findings suggest that race-specific interpretations of spirometry may be normalizing structural racial inequities in respiratory health rather than identifying true biological differences in lung function.

Reference: "Race-based spirometry equations may miss emphysema"; AMERICAN COLLEGE OF PHYSICIANS; Annals of Internal Medicine, DOI:10.7326/M22-0205.

Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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