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AJR systematic review and meta-analysis on MRI surveillance for postsurgical musculoskeletal soft-tissue sarcomas

Published On 2023-02-04T09:15:08+05:30  |  Updated On 4 Feb 2023 10:07 AM GMT
AJR systematic review and meta-analysis on MRI surveillance for postsurgical musculoskeletal soft-tissue sarcomas
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Overview

According to an accepted manuscript published in ARRS' American Journal of Roentgenology (AJR), MRI-based surveillance after surgical treatment of musculoskeletal soft-tissue sarcomas (STS) shows utility for detecting clinically occult local recurrences (LRs), potentially improving patient outcomes.

In this AJR systematic review and meta-analysis, Gorelik et al. systematically searched multiple electronic databases through November 2022 for controlled trials and cohort studies on the usefulness of MRI-based surveillance for musculoskeletal STS. A total of 4,821 unique titles and abstracts were identified. After screening for eligibility and snowball sampling, 19 studies were included; all were retrospective cohorts.

Using an adapted Newcastle-Ottawa scale for assessing bias risk, random effects meta-analyses of the proportion of LRs discovered by MRI, as opposed to clinically, were conducted. The association of low- versus high-intensity surveillance—high intensity defined as at least one local surveillance imaging examination for low-risk tumors, as well as at least three for high-risk tumors during the first 2 posttreatment years—with the proportion of LR detected on MRI was assessed with a chi-square test of subgroup differences.

Ultimately, when MRI-based surveillance of musculoskeletal STSs was used at a high intensity, 53% (95% CI, 36–71%) of LRs were discovered with MRI. Four studies reported trends toward better survival for imaging-detected LRs or with more frequent imaging use.

Reference:

Usefulness of MRI-based local surveillance after surgical treatment of musculoskeletal soft-tissue sarcomas: A systematic review and meta-analysis,American Journal of Roentgenology,doi 10.2214/AJR.22.28865

Speakers

Isra Zaman

B.Sc Life Sciences, M.Sc Biotechnology, B.Ed

Isra Zaman is a Life Science graduate from Daulat Ram College, Delhi University, and a postgraduate in Biotechnology from Amity University. She has a flair for writing, and her roles at Medicaldialogues include that of a Sr. content writer and a medical correspondent. Her news pieces cover recent discoveries and updates from the health and medicine sector. She can be reached at editorial@medicaldialogues.in.
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