A Healthy Lifestyle in Men at Increased Genetic Risk for Prostate Cancer - Video

Published On 2022-05-31T09:15:08+05:30 | Updated On 31 May 2022 9:15 AM IST

Overview

A study in European Urology examined whether men at an increased genetic risk of prostate cancer can offset their risk of disease or disease progression by adhering to a healthy lifestyle. Findings suggest that a genetic predisposition for prostate cancer is not deterministic for a poor cancer outcome. Maintaining a healthy lifestyle may provide a way to offset the genetic risk of lethal prostate cancer.

Study prospectively followed 12 411 genotyped men in the Health Professionals and the Physicians Health Study. Genetic risk of prostate cancer was quantified using a polygenic risk score (PRS). A healthy lifestyle with weight, vigorous physical activity, not smoking, and a healthy diet.

A total of 3005 overall prostate cancer and 435 lethal prostate cancer events were observed. The polygenic risk score enabled risk stratification not only for overall prostate cancer, but also for lethal disease with a four-fold difference between men in the highest and lowest quartiles 4.32. Among men in the highest PRS quartile, adhering to a healthy lifestyle was associated with a decreased rate of lethal prostate cancer 0.55, compared with having an unhealthy lifestyle, translating to a lifetime risk of 1.6% among the healthy and 5.3% among the unhealthy. Adhering to a healthy lifestyle was not associated with a decreased risk of overall prostate cancer.

These findings suggest that a genetic predisposition for prostate cancer is not deterministic for a poor cancer outcome. Maintaining a healthy lifestyle may provide a way to offset the genetic risk of lethal prostate cancer concluded the authors.

Speakers

Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751