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Everolimus after surgery improves outcomes in high-risk kidney cancer patients - Video

Published On 2022-06-06T09:00:54+05:30  |  Updated On 6 Jun 2022 3:50 PM IST
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Overview

In a study of patients with high-risk renal cell carcinoma, those who took the drug everolimus daily for up to one year after surgery lived longer without their disease returning than those who did not take everolimus. Improvement was seen primarily in patients with very high-risk disease, while patients with intermediate high-risk disease saw no improvement in recurrence-free survival.

The results from the EVEREST study, were presented at the 2022 annual meeting of the American Society of Clinical Oncology (ASCO).

The EVEREST trial enrolled patients who had been diagnosed with intermediate high-risk or very high-risk renal cell carcinoma and who had had their cancer surgically removed by a partial or radical nephrectomy. The study randomized 1,545 of these patients to a year of either everolimus (a 10 mg pill daily) or a placebo, starting within 12 weeks of their surgery.

EVEREST patients with very high-risk disease who took the drug saw a 21% improvement in recurrence-free survival, whereas recurrence-free survival was essentially unchanged for those in the intermediate high-risk group.

Adverse events such as oral mucositis led many patients to discontinue treatment. While, on the everolimus arm, 37 % of patients stopped treatment because of adverse events they were experiencing. In fact, only 45% of patients on the everolimus arm completed all 54 weeks of study treatment, versus 69 % on the placebo arm.

Researchers noted that inspite of more drop outs, they still observed favorable results for everolimus, which brings into question the duration of adjuvant therapy that is actually needed.

Speakers

Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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