Ferumoxytol: An effective and safe remedy for iron deficiency anemia, finds study
Iron deficiency anemia is the most common form of anemia and hematologic problem worldwide. Treatment options include oral or intravenous (IV) iron replacement. Although oral iron is commonly employed as first-line therapy, many studies suggest that IV iron more effective and associated with a better quality of life when compared to oral iron. Yet, adverse infusion reactions are possible.
There are multiple intravenous (IV) iron formulations available, of which several may be administered as single‐dose infusions such as low-molecular-weight iron dextran (LMWID), ferumoxytol, ferric carboxymaltose, and ferric derisomaltose. However, the administration of ferumoxytol as a single‐dose infusion is off‐label as it is approved as a 2‐dose series.
Researchers have found in a new study that the use of single-dose ferumoxytol for the treatment of iron deficiency anemia appears to be safe and effective compared with single-dose low molecular weight iron dextran, with a similar efficacy profile and a reduced need for repeated IV iron infusions.
Single‐dose ferumoxytol is considered effective and safe, and those patients may require fewer additional infusions compared to patients who received low-molecular-weight iron dextran (LMWID), according to recent research published in the America Journal of Hematology.
Although previous studies of ferumoxytol alone support the effectiveness and safety of the single‐dose regimen, there is a paucity of data directly comparing single‐dose ferumoxytol to other single‐dose IV iron formulations, he adds.
In his study, Jonathan and his colleagues included an overall of 906 patients who received single‐dose LMWID or ferumoxytol, and all these patients were included for the secondary analysis evaluating the incidence of adverse events (AE) and the requirement of additional IV iron infusions.
The findings of the research are-
a. Median change in Hb, Hct, and ferritin was not significantly different between groups.
b. Both groups experienced similar rates of AEs.
c. LMWID patients more frequently required additional IV iron infusions.
Based on the results, the researchers conclude that "single‐dose ferumoxytol is effective and safe compared to patients who received LMWID for the treatment of iron deficiency."