Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • Medical Jobs
  • Medical Matrimony
  • MD Brand Connect
  • MDTV
    • Anesthesia
    • CTVS
    • Cardiology
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • Diet and nutrition
    • ENT
    • Gastroenterology
    • Health Dialogues
    • Health News today
    • Health Shorts
    • Health Updates
    • Health video of the day
    • Laboratory Medicine
    • Latest Videos
    • Latest Webinars
    • MD shorts
    • Medical News Today
    • Medical Updates
    • Medical Video of the day
    • Medicine
    • Medico Legal Update
    • Nephrology
    • Neurology and Neurosurgery
    • Obstetrics and Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics & Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Top Videos
    • Urology
Medical Dialogues
  • Medical News
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • MCI News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Medical Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Aborad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Anesthesia
      • CTVS
      • Cardiology
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • Diet and nutrition
      • ENT
      • Gastroenterology
      • Health Dialogues
      • Health News today
      • Health Shorts
      • Health Updates
      • Health video of the day
      • Laboratory Medicine
      • Latest Videos
      • Latest Webinars
      • MD shorts
      • Medical News Today
      • Medical Updates
      • Medical Video of the day
      • Medicine
      • Medico Legal Update
      • Nephrology
      • Neurology and Neurosurgery
      • Obstetrics and Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics & Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Top Videos
      • Urology
      • Journal Club
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • MCI News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Medical Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Aborad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Medicine
  • Medicine News
  • Fish Oil found to Ease...

Fish Oil found to Ease Post-Operative Delirium in Pre-Clinical Studies

Dr. Kamal Kant KohliWritten by Dr. Kamal Kant Kohli Published On 2022-07-01T07:45:07+05:30  |  Updated On 2022-07-01T11:05:38+05:30
Fish Oil found to Ease Post-Operative Delirium in Pre-Clinical Studies

Delirium is a common complication of general surgery, particularly in older adults, that causes confusion, disorientation or a sudden change in mental abilities. At present there are no approved therapies this health condition.Researchers at Duke Health and Duke Biomedical Engineering have found in a new study that Fish oil triglycerides appear to be effective at reducing instances...

Delirium is a common complication of general surgery, particularly in older adults, that causes confusion, disorientation or a sudden change in mental abilities. At present there are no approved therapies this health condition.

Researchers at Duke Health and Duke Biomedical Engineering have found in a new study that Fish oil triglycerides appear to be effective at reducing instances of inflammation in the brain and preventing post-surgical delirium in mice and tissue engineered human models.The findings point to a potential new therapeutic approach for delirium.

The findings of the study have been published in the British Journal of Anaesthesia.

"Delirium is a prevalent complication with significant implications," said Niccolò Terrando, Ph.D., lead author of the study and associate professor in the Department of Anesthesiology at the Duke University School of Medicine.

"There is a very strong association between delirium and poorer outcomes, including mortality, especially in older and vulnerable adults," Terrando said. "There is also evidence that suggests an episode of delirium can lead to an accelerated trajectory for further cognitive impairments and greater risk for developing dementia."

Researchers administered a fish oil lipid injectable emulsion to mice before orthopedic surgery, a common trigger for delirium in the clinic. The injectable substance is already FDA-approved for use in children who have a specific condition affecting liver bile flow (parenteral nutrition-associated cholestasis).

Mice that received the fish oil did not show behavioral signs of delirium or associated brain pathology after surgery. The treated animals also exhibited less inflammation in the brain, with specific protection at new cellular targets in the blood-brain barrier. These targets, specifically pericytes and perivascular macrophages, become dysfunctional after anesthesia and surgery.

The researchers further confirmed their findings using a brain-on-chip model involving human cells in a tissue engineered environment, which demonstrated the beneficial effect of omega-3 fatty acids in maintaining the resilience of the blood-brain barrier in the presence of inflammation.

Terrando said this is one of the first studies to use this technology in the field of anesthesia, but further studies are needed to determine best practices for the application.

This research points to a potential screening approach that could help patients who are most at risk for developing delirium and are most vulnerable to deteriorating outcomes.

"If we can generate a brain-on-chip environment with cells from a patient who might be at risk for delirium and use this tool as a stress test-as a way to interrogate specific brain-related biology that might become deranged after surgery-that would open new opportunities to treat patients for a specific pathway that might be dysfunctional," Terrando said.

While delirium may increase a person's risk for developing neurodegenerative diseases like dementia, it's patients with dementia who are most acutely affected by this impairment because of current diagnostic and treatment limitations.

Delirium is mainly diagnosed by examining specific aspects of a person's cognitive abilities, such as the ability to conceptualize and process information. There are no reliable biomarkers for this complication, which makes its diagnosis in patients with ongoing neurodegeneration particularly challenging to detect.

"Delirium is still often underreported or underrecognized," Terrando said. "If we can harness technologies like organ-on-chip to deconstruct complex neuro-immune interactions impaired by surgical trauma, we may be able to identify specific targets and develop more personalized therapies to curtail these common neurological complications."

Reference:

Ting Yang, Ravikanth Velagapudi, Cuicui Kong, Unghyeon Ko, Vardhman Kumar, Paris Brown, Nathan O. Franklin, Xiaobei Zhang, Ana I. Caceres, Hyunjung Min, Anthony J. Filiano, Ramona M. Rodriguiz, William C. Wetsel, Shyni Varghese, Niccolò Terrando, Published:June 28, 2022 DOI: https://doi.org/10.1016/j.bja.2022.05.025

British Journal of Anaesthesia Fish Oil Omega-3 fatty acids blood-brain inflammation brain surgery delirium mental abilities Post-operative delirium POD 
Source : British Journal of Anaesthesia
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Before Joining Medical Dialogues, he has served at important positions in the medical industry in India including as the Hony. Secretary of the Delhi Medical Association as well as the chairman of Anti-Quackery Committee in Delhi and worked with other Medical Councils in India. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

    Show Full Article
    Next Story
    Similar Posts
    NO DATA FOUND

    Editorial

    Journal Club Today

    Health News Today

    © 2022 All Rights Reserved.
    Powered By: Hocalwire
    We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok
    X
    X