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Multivalent mRNA vaccine candidate another step closer to universal flu vaccine

Claudia Arevalo and colleagues have developed a mRNA lipid nanoparticle vaccine that contains antigens from all 20 known subtypes of influenza A and B viruses, a strategy that may serve as the basis for universal flu vaccines. Their vaccine produced high levels of cross-reactive and subtype-specific antibodies in mice and ferrets and could protect animals against disease symptoms and death...
Claudia Arevalo and colleagues have developed a mRNA lipid nanoparticle vaccine that contains antigens from all 20 known subtypes of influenza A and B viruses, a strategy that may serve as the basis for universal flu vaccines. Their vaccine produced high levels of cross-reactive and subtype-specific antibodies in mice and ferrets and could protect animals against disease symptoms and death after infection with both antigenically matched and mismatched strains of influenza. Even with increased global surveillance, it is difficult to predict which flu strain will cause the next flu pandemic, making a universal vaccine important.
The approach by Arevalo et al. differs from previous attempts to craft a universal flu vaccine by including antigens specific to each subtype, rather than just a smaller set of antigens shared among subtypes. Following on the success of mRNA vaccines against SARS-CoV-2, the researchers prepared 20 different nanoparticle encapsulated mRNAs, each encoding a different hemagglutinin antigen-a highly immunogenic flu protein that helps the virus enter cells. Antibody levels remained mostly stable four months after vaccination in the mice.
Multivalent protein vaccines produced using more traditional methods elicited fewer antibodies and were less protective compared to the multivalent mRNA vaccine in the animals. In a related Perspective, Alyson Kelvin and Darryl Falzarano discuss the results, noting that "questions remain regarding the regulation and approval pathway of such a vaccine that targets viruses of pandemic potential but are not currently in human circulation."
Reference:
Claudia P. Arevalo, Marcus J. Bolton, Valerie Le Sage, Colleen Furey, Hiromi Muramatsu, Mohamad-Gabriel Alameh, Norbert Pardi, Elizabeth M. Drapeau Kaela Parkhouse, Tyler Garretson, Jeffrey S. Morris, Louise H. Moncla, Ying K. Tam, Steven H. Y. Fan, Seema S. Lakdawala, Drew Weissman, Scott E. Hensley SCIENCE 24 Nov 2022 DOI: 10.1126/science.abm0271
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Before Joining Medical Dialogues, he has served at important positions in the medical industry in India including as the Hony. Secretary of the Delhi Medical Association as well as the chairman of Anti-Quackery Committee in Delhi and worked with other Medical Councils in India. Email: editorial@medicaldialogues.in. Contact no. 011-43720751