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  • Pfizer jab after first...

Pfizer jab after first AstraZeneca dose safe and highly effective: Study

Written By : Dr Kartikeya Kohli |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-05-20T15:55:37+05:30  |  Updated On 21 May 2021 3:31 PM IST
Pfizer jab after first AstraZeneca dose safe and highly effective: Study
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Researchers have been toying with idea of mixing Vaccines against COVID 19 for increasing their efficacy and overcome shortage of Vaccines.

Preliminary results of a spanish study on mixing COVID-19 vaccines have conveyed that giving a dose of Pfizer's drug to people who already received a first shot of AstraZeneca vaccine is highly safe and effective.

The government-led Combivacs study by investigators at Spain's CARLOS III Health Institute has revealed that people who got the second Pfizer shot after a jab of AstraZeneca vaccine had 30 and 40 times
higher
IgG antibodies compared to control group who only received one AstraZeneca dose.
The researchers engaged around 670 volunteers aged between 18-59 years in five major hospitals across Spain in the study. The participants had received their first dose of AstraZeneca vaccine, with about 450 people receiving the Pfizer vaccine for their second dose.
It was noticed that after administration of the Pfizer dose, the presence of neutralising antibodies rose sevenfold.

Just 1.7 per cent of the participants reported severe side effects, which were limited to headaches, muscle pain and general malaise, said Dr Magdalena Campins, one of the study's leaders.

"These are not symptoms that can be considered serious," she said.

Spain undertook the study to determine how best to proceed after limiting AstraZeneca's shot to people aged over 60 due to concerns about blood clotting in younger people.

In a U.K. "mix-and-match" study, first findings recently showed that people vaccinated with a shot of Pfizer's vaccine followed by a dose of AstraZeneca's, or vice versa, were more likely to report mild or moderate symptoms such as headaches or chills than if they received two of the same type. Data on immune responses are expected in the coming months.

That restriction caused widespread uncertainty and meant some younger people who had already received a first dose have been excluded from getting a second.

"Today's results support the possibility of vaccinating patients who have received the first dose from AstraZeneca, but the decision is not up to the investigators of this study," said Jesus Antonio Frias, clinical director at Carlos III.

Pfizer VaccinecoronavirusCOVID-19Vaccinationvaccinejab after first AstraZeneca Vaccine safeeffectiveCombivacs study
Source : With inputs from Hindustan Times
Dr Kartikeya Kohli
Dr Kartikeya Kohli

    Dr Kartikeya Kohli is an Internal Medicine Consultant at Sitaram Bhartia Hospital in Delhi with super speciality training in Nephrology. He has worked with various eminent hospitals like Indraprastha Apollo Hospital, Sir Gangaram Hospital. He holds an MBBS from Kasturba Medical College Manipal, DNB Internal Medicine, Post Graduate Diploma in Clinical Research and Business Development, Fellow DNB Nephrology, MRCP and ECFMG Certification. He has been closely associated with India Medical Association South Delhi Branch and Delhi Medical Association and has been organising continuing medical education programs on their behalf from time to time. Further he has been contributing medical articles for their newsletters as well. He is also associated with electronic media and TV for conduction and presentation of health programs. He has been associated with Medical Dialogues for last 3 years and contributing articles on regular basis.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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